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[CAS NO. 1360705-96-9] ML-210
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-100003 |
| Brand: | MCE |
| CAS: | 1360705-96-9 |
Overview
| MDL | MFCD22666407 |
|---|---|
| Molecular Weight | 475.32 |
| Molecular Formula | C22H20Cl2N4O4 |
| SMILES | O=C(N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1)C4=NOC(C)=C4[N+]([O-])=O |
3 Publications Citing Use of MCE
Summary
ML-210 is a selective and covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC 50 of 30 nM. ML-210 binds the GPX4 selenocysteine residue. ML-210 has anti-cancer activity [1] [2] .
IC50 & Target
Glutathione Peroxidase 4 (GPX4) [1]
In Vitro
ML-210 exhibits cell-killing activity across a panel of 821 cancer cell lines (WM88, LOX-IMVI, CJM, U257, CAKI2, A498, HT1080, MC38, PANC02). ML-210 is a prodrug that requires cellular activation to bind GPX4
[1]
.
ML-210 has
IC
50
s of 71 nM, 272 nM and 107nM for BJeLR (HRAS
V12
), BJeH-LT (without HRAS
V12
) and DRD cell lines, respectively
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 25 mg/mL ( 52.60 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.1038 mL | 10.5192 mL | 21.0385 mL |
| 5 mM | 0.4208 mL | 2.1038 mL | 4.2077 mL |
| 10 mM | 0.2104 mL | 1.0519 mL | 2.1038 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (4.38 mM); Clear solution
References
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