[CAS NO. 136152-65-3] (S)-(+)-Dimethindene maleate
PRODUCTS SPECIFICATIONS [136152-65-3]
DESCRIPTION [136152-65-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 408.49 |
| Molecular Formula | C24H28N2O4 |
| SMILES | C[C@@H](C1=C(CCN(C)C)CC2=C1C=CC=C2)C3=NC=CC=C3.OC(/C=C\C(O)=O)=O |
Summary
(S)-(+)-Dimethindene maleate, an enantiomer, is a potent M 2 -selective muscarinic receptor antagonist ( pA 2 = 7.86/7.74; pK i = 7.78). (S)-(+)-Dimethindene maleate shows lower affinities for the muscarinic M 1 (pA 2 = 6.83/6.36; pK i = 7.08), the M 3 (pA 2 = 6.92/6.96; pK i = 6.70) and the M 4 receptors (pK i = 7.00), respectively. (S)-(+)-Dimethindene maleate also is a histamine H 1 receptor antagonist ( pA 2 = 7.48) [1] .
IC50 & Target
|
mAChR2 7.78 (pKi) |
mAChR1 7.08 (pKi) |
mAChR4 7.00 (pKi) |
mAChR3 6.70 (pKi) |
H 1 Receptor 7.48 (pA2) |
In Vitro
(S)-(+)-Dimethindene maleate (2 μM; 1 h) significantly impaires the developmental potency of mouse extended pluripotent stem (mEPS) cells in chimeric blastocysts and leads to rapid differentiation of primed human pluripotent stem cell (hPSC)-converted hEPS cells [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [2]
| Cell Line: | Mouse EPS cells |
| Concentration: | 2 μM |
| Incubation Time: | 1 hour |
| Result: | Significantly impaired the developmental potency of mEPS cells. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL ( 244.80 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4480 mL | 12.2402 mL | 24.4804 mL |
| 5 mM | 0.4896 mL | 2.4480 mL | 4.8961 mL |
| 10 mM | 0.2448 mL | 1.2240 mL | 2.4480 mL |
References