[CAS NO. 1363421-46-8] MOMIPP
PRODUCTS SPECIFICATIONS [1363421-46-8]
DESCRIPTION [1363421-46-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 292.33 |
| Molecular Formula | C18H16N2O2 |
| SMILES | O=C(/C=C/C1=C(NC2=C1C=C(C=C2)OC)C)C3=CC=NC=C3 |
Summary
In Vitro
MOMIPP can induce intense macropinocytosis, leading to methuosis in cultured glioblastoma cells at low micromolar concentrations
[1]
.
In U373 and Hs683 cell lines, 3 µM for MOMIPP induces cell vacuolization
[1]
.
MOMIPP (10 μM) causes early disruptions of glucose uptake and glycolytic metabolism. MOMIPP selectively activates the JNK1/2 stress kinase pathway, resulting in phosphorylation of c-Jun, Bcl-2 and Bcl-xL
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis [2]
| Cell Line: | U251 cells |
| Concentration: | 10 μM |
| Incubation Time: | 4 h or 24 h |
| Result: | Activated the JNK stress kinase pathway. |
In Vivo
MOMIPP (80 mg/kg; i.p.; once daily; for 15 consecutive days) shows moderately effective in suppressing progression of intracerebral glioblastoma xenografts [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: |
Athymic CrTac:NCR-Foxn1
|
| Dosage: | 80 mg/kg |
| Administration: | i.p.; once daily; for 15 consecutive days |
| Result: | Suppressed progression of intracerebral glioblastoma xenografts. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 31.25 mg/mL ( 106.90 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.4208 mL | 17.1040 mL | 34.2079 mL |
| 5 mM | 0.6842 mL | 3.4208 mL | 6.8416 mL |
| 10 mM | 0.3421 mL | 1.7104 mL | 3.4208 mL |
References
- [1] Margaux Colin, et al. Dysregulation of Macropinocytosis Processes in Glioblastomas May Be Exploited to Increase Intracellular Anti-Cancer Drug Levels: The Example of Temozolomide. Cancers (Basel). 2019 Mar 22;11(3):411.
- [2] Zehui Li, et al. The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma. BMC Cancer. 2019 Jan 16;19(1):77.