[CAS NO. 13803-65-1] Anhydrotetracyclinehydrochloride

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PRODUCTS SPECIFICATIONS [13803-65-1]

Catalog

HY-118660

Brand

MCE

CAS

13803-65-1

DESCRIPTION [13803-65-1]

Overview

MDL	MFCD00151453
Molecular Weight	462.88
Molecular Formula	C22H23ClN2O7
SMILES	O=C(C(C1=O)=C(O)[C@@H](N(C)C)[C@]2([H])CC3=C(C([C@@]21O)=O)C(O)=C4C(O)=CC=CC4=C3C)N.[H]Cl

For research use only. We do not sell to patients.

Summary

Anhydrotetracycline hydrochloride, a tetracycline biosynthetic precursor, is a potent competitive broad-spectrum tetracycline destructase enzymes inhibitor. Anhydrotetracycline hydrochloride is an effector for tetracycline controlled gene expression systems in eukaryotic cells ^[1] .

IC50 & Target

Tetracycline

In Vitro

Anhydrotetracycline hydrochloride inhibits Tet(50) (IC ₅₀ =210 μM),Tet(X) (IC ₅₀ =41 μM), Tet(X)_3 (IC ₅₀ =3 μM) degradations of tetracyclines. Anhydrotetracycline hydrochloride inhibits Tet(50) (IC ₅₀ =210 μM),Tet(X) (IC ₅₀ =75 μM), Tet(X)_3 (IC ₅₀ =26 μM) degradations of chlortetracycline. Anhydrotetracycline hydrochloride inhibits Tet(50) (IC ₅₀ =120 μM),Tet(X) (IC ₅₀ =41 μM), Tet(X)_3 (IC ₅₀ =7 μM) degradations of demeclocycline ^[1] .
Anhydrotetracycline hydrochloride inhibits Tet(50) (IC ₅₀ =210 μM),Tet(X) (IC ₅₀ =41 μM), Tet(X)_3 (IC ₅₀ =3 μM) degradations of tetracyclines. Anhydrotetracycline hydrochloride inhibits Tet(50) (IC ₅₀ =210 μM),Tet(X) (IC ₅₀ =75 μM), Tet(X)_3 (IC ₅₀ =26 μM) degradations of chlortetracycline. Anhydrotetracycline hydrochloride inhibits Tet(50) (IC ₅₀ =120 μM),Tet(X) (IC ₅₀ =41 μM), Tet(X)_3 (IC ₅₀ =7 μM) degradations of demeclocycline ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 20.83 mg/mL ( 45.00 mM ; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1604 mL	10.8019 mL	21.6039 mL
5 mM	0.4321 mL	2.1604 mL	4.3208 mL
10 mM	0.2160 mL	1.0802 mL	2.1604 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 2.08 mg/mL (4.49 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (4.49 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Jana L Markley, et al. Semisynthetic Analogues of Anhydrotetracycline as Inhibitors of Tetracycline Destructase Enzymes. ACS Infect Dis. 2019 Apr 12;5(4):618-633.

Synonyms

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-, hydrochloride (1:1), (4S,4aS,12aS)-

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-, monohydrochloride

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-, monohydrochloride, [4S-(4α,4aα,12aα)]-

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-, monohydrochloride, (4S,4aS,12aS)-

Anhydrotetracycline hydrochloride