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Catalog: | HY-123918 |
Brand: | MCE |
CAS: | 1380392-05-1 |
MDL | MFCD30489012 |
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Molecular Weight | 419.95 |
Molecular Formula | C25H26ClN3O |
SMILES | O=C1C2=CC=CN2C3=C(C=CC=C3)N1CCCN4CCC(C5=CC=C(Cl)C=C5)CC4 |
IC50: 0.32 nM (CX3CR1) [1]
JMS-17-2 (10 mg/kg; aministered i.p.; twice a day for three weeks) causes a dramatic reduction of tumors in both skeleton and visceral organs in SCID mice [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model: | SCID mice (~25g) with MDA-231 xenograft [1] |
Dosage: | 10 mg/kg |
Administration: | Aministered i.p.; twice a day for three weeks |
Result: | Caused a dramatic reduction of tumors in both skeleton and visceral organs. |
Solid
Room temperature in continental US; may vary elsewhere.
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
DMSO : 25 mg/mL ( 59.53 mM ; Need ultrasonic)
Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
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1 mM | 2.3812 mL | 11.9062 mL | 23.8124 mL |
5 mM | 0.4762 mL | 2.3812 mL | 4.7625 mL |
10 mM | 0.2381 mL | 1.1906 mL | 2.3812 mL |
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (4.95 mM); Clear solution
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