[CAS NO. 1380392-05-1] JMS-17-2
PRODUCTS SPECIFICATIONS [1380392-05-1]
DESCRIPTION [1380392-05-1]
Overview
| MDL | MFCD30489012 |
|---|---|
| Molecular Weight | 419.95 |
| Molecular Formula | C25H26ClN3O |
| SMILES | O=C1C2=CC=CN2C3=C(C=CC=C3)N1CCCN4CCC(C5=CC=C(Cl)C=C5)CC4 |
1 Publications Citing Use of MCE
Summary
IC50 & Target
IC50: 0.32 nM (CX3CR1) [1]
In Vivo
JMS-17-2 (10 mg/kg; aministered i.p.; twice a day for three weeks) causes a dramatic reduction of tumors in both skeleton and visceral organs in SCID mice [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | SCID mice (~25g) with MDA-231 xenograft [1] |
| Dosage: | 10 mg/kg |
| Administration: | Aministered i.p.; twice a day for three weeks |
| Result: | Caused a dramatic reduction of tumors in both skeleton and visceral organs. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 25 mg/mL ( 59.53 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3812 mL | 11.9062 mL | 23.8124 mL |
| 5 mM | 0.4762 mL | 2.3812 mL | 4.7625 mL |
| 10 mM | 0.2381 mL | 1.1906 mL | 2.3812 mL |
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Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (4.95 mM); Clear solution