[CAS NO. 1384424-80-9] A 1070722
PRODUCTS SPECIFICATIONS [1384424-80-9]
DESCRIPTION [1384424-80-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 362.31 |
| Molecular Formula | C17H13F3N4O2 |
| SMILES | FC(F)(F)C1=NC(NC(NC2=CC=NC3=C2C=CC(OC)=C3)=O)=CC=C1 |
Summary
A 1070722 is a potent and selective glycogen synthase kinase 3 (GSK-3) inhibitor, with a K i of 0.6 nM for both GSK-3α and GSK-3β . A 1070722 can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain [1] .
IC50 & Target
|
GSK-3α 0.6 nM (Ki) |
GSK-3β 0.6 nM (Ki) |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 83.33 mg/mL ( 230.00 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.7601 mL | 13.8003 mL | 27.6007 mL |
| 5 mM | 0.5520 mL | 2.7601 mL | 5.5201 mL |
| 10 mM | 0.2760 mL | 1.3800 mL | 2.7601 mL |