[CAS NO. 1394285-50-7]  Golgicide A-2

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PRODUCTS SPECIFICATIONS [1394285-50-7]

Catelog
HY-100540B
Brand
MCE
CAS
1394285-50-7

DESCRIPTION [1394285-50-7]

Overview

MDL-
Molecular Weight284.30
Molecular FormulaC17H14F2N2
SMILESFC1=CC2=C(N[C@@H](C3=CC=CN=C3)[C@]4([H])[C@@]2([H])C=CC4)C(F)=C1

For research use only. We do not sell to patients.

Summary

Golgicide A-2 (GCA-2), a Golgicide A (GCA) derivative, is the most active enantiomer of GCA. Golgicide A-2 displays high selectivity and efficiency in killing An. stephensi larvae and can be used for the research of dengue virus related diseases [1] .


In Vitro

GCA-2 is effective in killing both Ae. Aegypti and An. Stephensi larvae, while it is displays distinct and strongly selective cytotoxicity towards Ae. Stephensi larvae with a mortality of 83.4% [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 351.74 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5174 mL 17.5871 mL 35.1741 mL
5 mM 0.7035 mL 3.5174 mL 7.0348 mL
10 mM 0.3517 mL 1.7587 mL 3.5174 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: 5 mg/mL (17.59 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: 5 mg/mL (17.59 mM); Clear solution; Need ultrasonic

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: 5 mg/mL (17.59 mM); Clear solution; Need ultrasonic

* All of the co-solvents are available by MCE.