[CAS NO. 140-66-9] 4-tert-Octylphenol

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PRODUCTS SPECIFICATIONS [140-66-9]

Catalog

HY-B1941

Brand

MCE

CAS

140-66-9

DESCRIPTION [140-66-9]

Overview

MDL	MFCD00002368
Molecular Weight	206.32
Molecular Formula	C14H22O
SMILES	OC1=CC=C(C(C)(C)CC(C)(C)C)C=C1

For research use only. We do not sell to patients.

Summary

4-tert-Octylphenol, a endocrine-disrupting chemical, is an estrogenic drug. 4-tert-Octylphenol induces apoptosis in neuronal progenitor cells in offspring mouse brain. 4-tert-Octylphenol reduces bromodeoxyuridine (BrdU), mitotic marker Ki67, and phospho-histone H3 (p-Histone-H3), resulting in a reduction of neuronal progenitor proliferation. 4-tert-Octylphenol disrupts brain development and behavior in mice ^[1] .

IC50 & Target

Human Endogenous Metabolite

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 484.68 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.8468 mL	24.2342 mL	48.4684 mL
5 mM	0.9694 mL	4.8468 mL	9.6937 mL
10 mM	0.4847 mL	2.4234 mL	4.8468 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (12.12 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (12.12 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (12.12 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Dinh Nam Tran, et al. 4-tert-Octylphenol Exposure Disrupts Brain Development and Subsequent Motor, Cognition, Social, and Behavioral Functions. Oxidative Medicine and Cellular Longevity, 2020.

Synonyms

Phenol, 4-(1,1,3,3-tetramethylbutyl)-

Phenol, p-(1,1,3,3-tetramethylbutyl)-

4-(1,1,3,3-Tetramethylbutyl)phenol

p-tert-Octylphenol

4-tert-Octylphenol

p-Octylphenol

p-(1,1,3,3-Tetramethylbutyl)phenol

4-Octylphenol

NSC 5427

NSC 7248

p-t-Octylphenol

4-(2,4,4-Trimethylpentan-2-yl)phenol

4-(2,2,4-Trimethylpentan-2-yl)phenol