[CAS NO. 1402345-92-9] GSK-F1

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PRODUCTS SPECIFICATIONS [1402345-92-9]

Catalog

HY-100603

Brand

MCE

CAS

1402345-92-9

DESCRIPTION [1402345-92-9]

Overview

MDL	-
Molecular Weight	603.52
Molecular Formula	C27H18F5N5O4S
SMILES	O=S(C1=CC(C2=CC3=C(N=C(N)N(C4=CC=CC=C4C(F)(F)F)C3=O)C=C2)=CN=C1OC)(NC5=CC=C(F)C=C5F)=O

For research use only. We do not sell to patients.

Summary

GSK-F1 (Compound F1) is an orally active PI4KA inhibitor with pIC ₅₀ values of 8.0, 5.9, 5.8, 5.9, 5.9 and 6.4 against PI4KA, PI4KB, PI3KA, PI3KB, PI3KG and PI3KD, respectively. GSK-F1 can be used for HCV infection research ^[1] .

IC50 & Target

PI4KA

8.0 (pIC ₅₀ )

PI3KD

6.4 (pIC ₅₀ )

PI4KB

5.9 (pIC ₅₀ )

PI3KB

5.9 (pIC ₅₀ )

PI3KG

5.9 (pIC ₅₀ )

PI3KA

5.8 (pIC ₅₀ )

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 207.12 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6569 mL	8.2847 mL	16.5695 mL
5 mM	0.3314 mL	1.6569 mL	3.3139 mL
10 mM	0.1657 mL	0.8285 mL	1.6569 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1] Bojjireddy N, et al. Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levels. J Biol Chem. 2014 Feb 28;289(9):612