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Catalog: | HY-148452 |
Brand: | MCE |
CAS: | 1402931-84-3 |
MDL | - |
---|---|
Molecular Weight | 500.54 |
Molecular Formula | C29H28N2O6 |
SMILES | COC1=CC=C([C@@]23OC4=CC(C#N)=CC(OC)=C4[C@]2(O)[C@@H]([C@@H]([C@H]3C5=CC=CC=C5)C(N(C)C)=O)O)C=C1 |
eIF4A3-IN-18 (compound 74) is a silvestrol (HY-13251) analogue. eIF4A3-IN-18 interferes the assembling of eIF4F translation complex with EC 50 values of 0.8, 35 and 2 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-18 also has cytotoxicity to RMPI-8226 cells with an LC 50 of 0.06 nM. eIF4A3-IN-18 can be used for the research of human cancer pathogenesis [1] .
Room temperature in continental US; may vary elsewhere.
Please store the product under the recommended conditions in the Certificate of Analysis.
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