[CAS NO. 1417162-36-7]  RI-2

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PRODUCTS SPECIFICATIONS [1417162-36-7]

Catalog
HY-16904
Brand
MCE
CAS
1417162-36-7

DESCRIPTION [1417162-36-7]

Overview

MDL-
Molecular Weight433.28
Molecular FormulaC21H18Cl2N2O4
SMILESO=C(C(C1=CC=C(OC)C=C1)=C2N3CCOCC3)N(C4=CC=C(Cl)C(Cl)=C4)C2=O

For research use only. We do not sell to patients.

Summary

RI-2 is a reversible RAD51 inhibitor, with an IC 50 of 44.17 μM, and specifically inhibits homologous recombination repair in human cells.


IC50 & Target

IC50: 44.17 μM (RAD51) [1]


In Vitro

RI-2 (7a) is a reversible RAD51 inhibitor, with an IC 50 of 44.17 μM. RI-2 specifically inhibits homologous recombination repair in human cells. RI-2 (150 μM) induces a significant sensitization of cells [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 130 mg/mL ( 300.04 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3080 mL 11.5399 mL 23.0798 mL
5 mM 0.4616 mL 2.3080 mL 4.6160 mL
10 mM 0.2308 mL 1.1540 mL 2.3080 mL
* Please refer to the solubility information to select the appropriate solvent.