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[CAS NO. 1417700-13-0] ML188
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-136259 |
| Brand: | MCE |
| CAS: | 1417700-13-0 |
Overview
| MDL | MFCD32693920 |
|---|---|
| Molecular Weight | 433.54 |
| Molecular Formula | C26H31N3O3 |
| SMILES | O=C(NC(C)(C)C)[C@@H](C1=CN=CC=C1)N(C(C=C2)=CC=C2C(C)(C)C)C(C3=CC=CO3)=O |
4 Publications Citing Use of MCE
Summary
In Vitro
ML188 (0-30 μM; 48 hours) effectively inhibit SARS-CoV replication in cell culture
[1]
.
Probe ML188 is a modest molecular weight SARS-CoV 3CLpro inhibitor with demonstrated antiviral activity and a non-covalent mechanism of action. ML188 yields an antiviral EC
50
value ranging from 12.9 to 13.4 μM in mock-infected and SARS-CoV infected cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | Vero E6 cells (mock-infected or infected with SARS-CoV) |
| Concentration: | 3, 4, 5, 8,10, 15, 20, 30 μM |
| Incubation Time: | 48 hour |
| Result: | Against mock-infected and SARS-CoV infected cells. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 250 mg/mL ( 576.65 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3066 mL | 11.5330 mL | 23.0659 mL |
| 5 mM | 0.4613 mL | 2.3066 mL | 4.6132 mL |
| 10 mM | 0.2307 mL | 1.1533 mL | 2.3066 mL |
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