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[CAS NO. 1418013-75-8] NMS-873
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-15713 |
| Brand: | MCE |
| CAS: | 1418013-75-8 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 520.67 |
| Molecular Formula | C27H28N4O3S2 |
| SMILES | CC(C=C(OCC1=NN=C(SC2CCCC2)N1C3=CC=CN=C3)C=C4)=C4C5=CC=C(S(=O)(C)=O)C=C5 |
6 Publications Citing Use of MCE
Summary
NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with an IC 50 value of 30 nM.
IC50 & Target
IC50: 30 nM [1]
In Vitro
NMS-873 has antiproliferative effect on a panel of tumor cell lines with IC 50 values in the range of 0.08 μM to 2 μM. For HCT116 and HeLa cells, the IC 50 values are 0.4 μM and 0.7 μM, respectively. NMS-873 reduces VCP sensitivity to trypsin digestion, preventing degradation of the linker-D2 domain. NMS-873 induces clear, dose-dependent accumulation of poly-Ub proteins and stabilization of cyclin E and Mcl-1 at doses consistent with its antiproliferative IC 50 value [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 20.5 mg/mL ( 39.37 mM ; Need ultrasonic and warming)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.9206 mL | 9.6030 mL | 19.2060 mL |
| 5 mM | 0.3841 mL | 1.9206 mL | 3.8412 mL |
| 10 mM | 0.1921 mL | 0.9603 mL | 1.9206 mL |
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