[CAS NO. 141977-79-9] Miriplatin

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PRODUCTS SPECIFICATIONS [141977-79-9]

Catelog

HY-16325A

Brand

MCE

CAS

141977-79-9

DESCRIPTION [141977-79-9]

Overview

MDL	MFCD04113190
Molecular Weight	764.00
Molecular Formula	C34H68N2O4Pt
SMILES	NC1CCCCC1N.[O-]C(CCCCCCCCCCCCC)=O.[O-]C(CCCCCCCCCCCCC)=O.[Pt+2]

For research use only. We do not sell to patients.

3 Publications Citing Use of MCE

Summary

Miriplatin (SM-11355) is a chemotherapy agent which belongs to the class of alkylating agents.

In Vitro

Miriplatin (SM-11355) suspended in LPD (miriplatin/LPD, 100 μg/mL) inhibits the growth of AH109A cells, forms platinum-DNA adducts, and induces apoptosis ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Miriplatin (SM-11355) (0.02-0.4 mg/20 μL) in lipiodol reduces tumor growth rates in a dose dependent manner in rats bearing AH109A tumor cells ^[1] . Miriplatin/LPD (400 μg/head) significantly reduces the growth of tumor in rats bearing AH109A cells ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

Acetone : < 1 mg/mL (ultrasonic) (insoluble ; DMSO can inactivate Miriplatin's activity)

DMF : < 1 mg/mL (insoluble ; DMSO can inactivate Miriplatin's activity)

H ₂ O : < 0.1 mg/mL (insoluble ; DMSO can inactivate Miriplatin's activity)

* Miriplatin is usually formulated as a suspension.

References

Synonyms

Platinum, [(1R,2R)-1,2-cyclohexanediamine-κN¹,κN²]bis(tetradecanoato-κO)-, (SP-4-2)-

Platinum, (1,2-cyclohexanediamine-κN,κN′)bis(tetradecanoato-κO)-, [SP-4-2-[1R-(trans)]]-

Platinum, [(1R,2R)-1,2-cyclohexanediamine-κN,κN′]bis(tetradecanoato-κO)-, (SP-4-2)-

(SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-κN¹,κN²]bis(tetradecanoato-κO)platinum

SM 11355

Platinum, (1,2-cyclohexanediamine-N,N′)bis(tetradecanoato-O)-, [SP-4-2-(1R-trans)]-

Cyclohexane-(1R,2R)-diamineplatinum(II) dimyristate

Miriplatin

[(1R,2R)-1,2-Cyclohexanediamine]bis(myristato)platinum

Miripla