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[CAS NO. 1422180-49-1] SBP-0636457
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-125378 |
| Brand: | MCE |
| CAS: | 1422180-49-1 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 456.58 |
| Molecular Formula | C25H36N4O4 |
| SMILES | O=C([C@@H]1C(C)(C)C[C@](N21)([H])OCC[C@H](NC([C@@H](NC)C)=O)C2=O)N[C@@H]3CCCC4=C3C=CC=C4 |
Summary
IC50 & Target
|
XIAP 0.27 μM (Ki) |
In Vitro
SBP-0636457 (1-20 μM) demonstrates no cytotoxicity in BT474, BT549, MCF7, and MDA-MB-231 breast cancer cell lines up to a concentration of 20μM
[1]
.
SBP-0636457 (10-1000 nM; 20 h) is efficacious as TRAIL-sensitizing agents in MDA-MB-231 cells, with an EC
50
of 9 nM
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 45.71 mg/mL ( 100.11 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.1902 mL | 10.9510 mL | 21.9020 mL |
| 5 mM | 0.4380 mL | 2.1902 mL | 4.3804 mL |
| 10 mM | 0.2190 mL | 1.0951 mL | 2.1902 mL |
References
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