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[CAS NO. 1422252-46-7] BI-9627hydrochloride
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-18071A |
| Brand: | MCE |
| CAS: | 1422252-46-7 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 392.80 |
| Molecular Formula | C16H20ClF3N4O2 |
| SMILES | NC(NC(C1=CC=C(C2CCN(C(C)=O)CC2)C(C(F)(F)F)=C1)=O)=N.Cl |
Summary
BI-9627 hydrochloride is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 hydrochloride displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 hydrochloride shows low DDI (drug-drug interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury [1] .
IC50 & Target
IC50: 6 nM (NHE1 in intracellular pH recovery assay), 31 nM (NHE1 in human platelet swelling assay) [1]
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL ( 254.58 mM ; Need ultrasonic)
H 2 O : 4.17 mg/mL ( 10.62 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.5458 mL | 12.7291 mL | 25.4583 mL |
| 5 mM | 0.5092 mL | 2.5458 mL | 5.0916 mL |
| 10 mM | 0.2546 mL | 1.2729 mL | 2.5458 mL |
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