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[CAS NO. 1423018-12-5] LY2922470
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-19835 |
| Brand: | MCE |
| CAS: | 1423018-12-5 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 475.60 |
| Molecular Formula | C28H29NO4S |
| SMILES | COC1=C(N(CC2=CC=C(COC3=CC=C([C@@H](C#CC)CC(O)=O)C=C3)S2)CCC4)C4=CC=C1 |
Summary
LY2922470 is a potent, selective and orally available agonist of the G protein-coupled receptor 40 (GPR40) , with EC 50 s of 7 nM, 1 nM and 3 nM for human GPR40, mouse GPR40 and rat GPR40, respectively. LY2922470 reduces glucose levels along with significant increases in insulin and GLP-1 , is potential for the treatment of type 2 diabetes mellitus (T2DM) [1] .
IC50 & Target
EC50：7 nM (human GPR40), 1 nM (mouse GPR40), 3 nM (rat GPR40) [1]
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT01867216 | Eli Lilly and Company |
Diabetes Mellitus, Type 2
|
June 2013 | Phase 1 |
| NCT01746017 | Eli Lilly and Company |
Diabetes Mellitus, Type 2
|
December 2012 | Phase 1 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : ≥ 125 mg/mL ( 262.83 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.1026 mL | 10.5130 mL | 21.0261 mL |
| 5 mM | 0.4205 mL | 2.1026 mL | 4.2052 mL |
| 10 mM | 0.2103 mL | 1.0513 mL | 2.1026 mL |
Synonyms
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