[CAS NO. 1425485-72-8] DBCO-C6-acid
PRODUCTS SPECIFICATIONS [1425485-72-8]
DESCRIPTION [1425485-72-8]
Overview
| MDL | MFCD22380737 |
|---|---|
| Molecular Weight | 333.38 |
| Molecular Formula | C21H19NO3 |
| SMILES | O=C(CCCCC(O)=O)N1CC2=C(C=CC=C2)C#CC3=C1C=CC=C3 |
Summary
DBCO-C6-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-C6-acid can be used in the synthesis of carmaphycin analogues [1] .
IC50 & Target
|
Non-cleavable |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 299.96 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.9996 mL | 14.9979 mL | 29.9958 mL |
| 5 mM | 0.5999 mL | 2.9996 mL | 5.9992 mL |
| 10 mM | 0.3000 mL | 1.4998 mL | 2.9996 mL |
-
1.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: 2.5 mg/mL (7.50 mM); Suspended solution; Need ultrasonic