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[CAS NO. 1426944-49-1] HBX 19818
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-17540 |
| Brand: | MCE |
| CAS: | 1426944-49-1 |
Overview
| MDL | MFCD28167744 |
|---|---|
| Molecular Weight | 421.96 |
| Molecular Formula | C25H28ClN3O |
| SMILES | CN(CCCNC(C1=CC=C(N=C(CCCC2)C2=C3Cl)C3=C1)=O)CC4=CC=CC=C4 |
11 Publications Citing Use of MCE
- [1]Cell Metab. 2019 May 7;29(5):1166-1181.e6.
- [2]Nat Chem Biol. 2017 Dec;13(12):1207-1215.
- [3]Nat Struct Mol Biol. 2016 Apr;23(4):270-7.
- [4]Cell Death Differ. 2022 Dec 16.
- [5]EMBO J. 2021 Apr 15;e99692.
- [6]Theranostics. 2020 Jul 23;10(20):9332-9347.
- [7]Br J Cancer. 2020 Sep;123(6):1012-1023.
- [8]Br J Cancer. 2020 Apr;122(8):1175-1184.
- [9]Mol Cell Biol. 2015 Apr 1;35(7):1157-68.
- [10]Dev Growth Differ. 2019 Feb;61(2):176-185.
- [11]Harvard Medical School LINCS LIBRARY
Summary
HBX 19818 is a specific inhibitor of ubiquitin-specific protease 7 (USP7) , with an IC 50 of 28.1 μM.
IC50 & Target
IC50: 28.1 μM (USP7) [1]
In Vitro
HBX 19818 is an inhibitor of USP7, with an IC 50 of 28.1 μM. HBX 19818 shows no effects on USP8, USP5, USP10, CYLD, UCH-L1, UCH-L3 or on SENP1, a SUMO protease, with IC 50 s of > 200 μM. HBX 19818 selectively inhibits USP7 with IC 50 of ∼6 μM in in human cancer cells. In addition, HBX 19818 (1.5, 4, 12, 36, or 100 μM) inhibits USP7 deubiquitination of polyubiquitinated p53. HBX 19818 (30 μM) also causes significantly higher levels of Mdm2 polyubiquitinated forms in USP7-overproducing HEK293 cells than those in DMSO-treated control cells. HBX 19818 inhibits HCT116 proliferation in a dose-dependent manner, with an IC 50 of ∼2 μM [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
1M HCl : 100 mg/mL ( 236.99 mM ; ultrasonic and adjust pH to 1 with HCl)
DMSO : 20 mg/mL ( 47.40 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3699 mL | 11.8495 mL | 23.6989 mL |
| 5 mM | 0.4740 mL | 2.3699 mL | 4.7398 mL |
| 10 mM | 0.2370 mL | 1.1849 mL | 2.3699 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2 mg/mL (4.74 mM); Clear solution
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