[CAS NO. 142796-21-2] Isosilybin A
PRODUCTS SPECIFICATIONS [142796-21-2]
DESCRIPTION [142796-21-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 482.44 |
| Molecular Formula | C25H22O10 |
| SMILES | O=C1[C@H](O)[C@@H](C2=CC=C(O[C@H](C3=CC=C(O)C(OC)=C3)[C@@H](CO)O4)C4=C2)OC5=CC(O)=CC(O)=C15 |
1 Publications Citing Use of MCE
Summary
Isosilybin A, a flavonolignan isolated from silymarin, has anti-prostate cancer (PCA) activity. Isosilybin A inhibits proliferation and induces G1 phase arrest and apoptosis in cancer cells, which activates apoptotic machinery in PCA cells via targeting Akt-NF-κB-androgen receptor (AR) axis [1] [2] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 207.28 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.0728 mL | 10.3640 mL | 20.7280 mL |
| 5 mM | 0.4146 mL | 2.0728 mL | 4.1456 mL |
| 10 mM | 0.2073 mL | 1.0364 mL | 2.0728 mL |
References
- [1] Deep G, et al. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostatecancer LNCaP and 22Rv1 cells. Carcinogenesis. 2007 Jul;28(7):1533-42.
- [2] Deep G, et al. Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-κB, and androgen receptor signaling. Mol Carcinog. 2010 Oct;49(10):902-12.