[CAS NO. 1429624-84-9] PI4KIIIbeta-IN-9
PRODUCTS SPECIFICATIONS [1429624-84-9]
DESCRIPTION [1429624-84-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 487.59 |
| Molecular Formula | C23H25N3O5S2 |
| SMILES | CC(N=C1NC(C2CCCC2)=O)=C(S1)C3=CC=C(C(S(=O)(NC4=CC=C(O)C=C4)=O)=C3)OC |
4 Publications Citing Use of MCE
Summary
IC50 & Target
|
PI4KIIIβ 7 nM (IC 50 ) |
PI4KIIIα 2.6 μM (IC 50 ) |
PI3Kδ 152 nM (IC 50 ) |
PI3Kγ 1046 nM (IC 50 ) |
PI3Kα 2 μM (IC 50 ) |
PI3KC2γ 1 μM (IC 50 ) |
In Vitro
PI4KIIIbeta-IN-9 (Compound 9) shows weak inhibition of PI3KC2γ (IC 50 ~1 µM), PI3Kα (~2 µM), and PI4KIIIα (~2.6 µM) and <50% inhibition at concentrations up to 20 µM for PI4K2α, PI4K2β, and PI3Kβ. PI4KIIIbeta-IN-9 (Compound 9) forms a crescent shape that conforms to the active site of PI4KIIIβ. This molecule makes extensive contacts with PI4KIIIβ [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 205.09 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.0509 mL | 10.2545 mL | 20.5090 mL |
| 5 mM | 0.4102 mL | 2.0509 mL | 4.1018 mL |
| 10 mM | 0.2051 mL | 1.0255 mL | 2.0509 mL |