[CAS NO. 1429934-37-1] Propargyl-PEG4-CH2COOH

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PRODUCTS SPECIFICATIONS [1429934-37-1]

Catalog

HY-140023

Brand

MCE

CAS

1429934-37-1

DESCRIPTION [1429934-37-1]

Overview

MDL	MFCD29079380
Molecular Weight	290.31
Molecular Formula	C13H22O7
SMILES	C#CCOCCOCCOCCOCCOCC(O)=O

For research use only. We do not sell to patients.

Summary

Propargyl-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs ^[1] .

IC50 & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Liquid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562