[CAS NO. 1432494-65-9] CKK-E12

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PRODUCTS SPECIFICATIONS [1432494-65-9]

Catalog

HY-134781

Brand

MCE

CAS

1432494-65-9

DESCRIPTION [1432494-65-9]

Overview

MDL	-
Molecular Weight	993.62
Molecular Formula	C60H120N4O6
SMILES	O=C(C(CCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)N1)NC(CCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)C1=O

For research use only. We do not sell to patients.

Summary

CKK-E12 is a ionizable lipid in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based therapeutics. cKK-E12 was highly selective toward liver parenchymal cell in vivo,

Appearance

Liquid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 50.32 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0064 mL	5.0321 mL	10.0642 mL
5 mM	0.2013 mL	1.0064 mL	2.0128 mL
10 mM	0.1006 mL	0.5032 mL	1.0064 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1] Dong Y, Love KT, Dorkin JR, et al. Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates [published correction appears in Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5753]. Proc Natl Acad Sci U S A. 2014;111(