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[CAS NO. 1435467-38-1] PF-1355
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-100873 |
| Brand: | MCE |
| CAS: | 1435467-38-1 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 321.35 |
| Molecular Formula | C14H15N3O4S |
| SMILES | O=C(N)CN(C(N1)=S)C(C2=CC(OC)=CC=C2OC)=CC1=O |
Summary
PF-1355 is a selective 2-thiouracil mechanism-based MPO inhibitor, used for treatment of vasculitic diseases.
In Vitro
In a dose-responsive fashion, PF-1355 inhibits MPO activity in phorbol ester-stimulated human neutrophils as measured by taurine chlorination (EC 50 =1.47 μM) as well as lipopolysaccharide-treated human blood measuring residual MPO activity (EC 50 =2.03 μM) [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Oral administration of PF-1355 reduces plasma MPO activity, vascular edema, neutrophil recruitment, and elevates circulating cytokines. In a model of anti-glomerular basement membrane disease, formerly known as Goodpasture disease, albuminuria and chronic renal dysfunction are completely suppressed by PF-1355 treatment [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 155.59 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.1119 mL | 15.5594 mL | 31.1187 mL |
| 5 mM | 0.6224 mL | 3.1119 mL | 6.2237 mL |
| 10 mM | 0.3112 mL | 1.5559 mL | 3.1119 mL |
Synonyms
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