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[CAS NO. 1436861-97-0] Zidebactam
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-120859 |
| Brand: | MCE |
| CAS: | 1436861-97-0 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 391.40 |
| Molecular Formula | C13H21N5O7S |
| SMILES | O=C([C@@H]1CCCNC1)NNC([C@@H]2CC[C@@H]3C[N@]2C(N3OS(=O)(O)=O)=O)=O |
3 Publications Citing Use of MCE
Summary
IC50 & Target
IC50: 0.26 μg/mL ( P. aeruginosa PAO1 PBP2) [2]
In Vitro
Zidebactam (WCK-5107) inhibits WT Enterobacteriaceae with a MIC 50 of 0.25 mg/L. Zidebactam alone exhibits variable activity when tested against E. coli (MIC 50/90 0.12/0.12 mg/L) and Enterobacter spp. (MIC 50/90 0.12/0.25 mg/L) [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT02532140 | Wockhardt|Quintiles, Inc. |
Healthy
|
August 2015 | Phase 1 |
| NCT02674347 | Wockhardt|Quintiles, Inc. |
Healthy Subjects
|
February 2016 | Phase 1 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 250 mg/mL ( 638.73 mM ; Need ultrasonic)
H 2 O : 50 mg/mL ( 127.75 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.5549 mL | 12.7747 mL | 25.5493 mL |
| 5 mM | 0.5110 mL | 2.5549 mL | 5.1099 mL |
| 10 mM | 0.2555 mL | 1.2775 mL | 2.5549 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (255.49 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
-
2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.08 mg/mL (5.31 mM); Clear solution
-
3.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (5.31 mM); Clear solution
-
4.
References
- [1] Sader HS, et al. WCK 5222 (cefepime/zidebactam) antimicrobial activity tested against Gram-negative organisms producing clinically relevant β-lactamases. J Antimicrob Chemother. 2017 Jun 1;72(6):1696-1703.
- [2] Moya B, et al. WCK 5107 (Zidebactam) and WCK 5153 Are Novel Inhibitors of PBP2 Showing Potent "β-Lactam Enhancer" Activity against Pseudomonas aeruginosa, Including Multidrug-Resistant Metallo-β-Lactamase-Producing High-Risk Clones. Antimicrob Agents Chem
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