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[CAS NO. 1438881-19-6] CRT0066854
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-18713 |
| Brand: | MCE |
| CAS: | 1438881-19-6 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 415.55 |
| Molecular Formula | C24H25N5S |
| SMILES | N[C@H](CNC1=NC(C2=CC=NC=C2)=NC3=C1C(CCCC4)=C4S3)CC5=CC=CC=C5 |
Summary
IC50 & Target
|
PKCζ 639 nM (IC 50 ) |
ROCK2 620 nM (IC 50 ) |
In Vitro
CRT0066854 displaces a crucial Asn-Phe-Asp motif that is part of the adenosine-binding pocket and engages an acidic patch used by arginine-rich PKC substrates
[1]
.
CRT0066854 (0.2-1.2 μM; 6 days) is able to restore polarized morphogenesis in the dysplastic H-Ras spheroids, and the maximal proportion of spheroids with PSALs is at the lower dose of 1.2 μM
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 120.32 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4064 mL | 12.0322 mL | 24.0645 mL |
| 5 mM | 0.4813 mL | 2.4064 mL | 4.8129 mL |
| 10 mM | 0.2406 mL | 1.2032 mL | 2.4064 mL |
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