[CAS NO. 144-68-3] Zeaxanthin
PRODUCTS SPECIFICATIONS [144-68-3]
DESCRIPTION [144-68-3]
Overview
| MDL | MFCD08435940 |
|---|---|
| Molecular Weight | 568.87 |
| Molecular Formula | C40H56O2 |
| SMILES | CC1(C)C(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C2=C(C)C[C@@H](O)CC2(C)C)=C(C)C[C@@H](O)C1 |
Summary
IC50 & Target
|
Microbial Metabolite |
Human Endogenous Metabolite |
In Vitro
Much of the Lutein and Zeaxanthin in the leaves of plants is protein-bound.In fruits and flower petals, the xanthophylls are esterified and are concentrated into chromoplasts where they are found to be solubilized in the membranes. In humans and higher animals, Lutein and Zeaxanthin are accumulated in lipophilic tissues such as adipose tissue and are carried in the blood by the lipoproteins, probably in a nonspecific manner similar to cholesterol. Lutein and Zeaxanthin are distributed equally between LDL and HDL fractions in human blood, in contrast to the hydrocarbon carotenoids that are preferentially found in LDL fractions, up to 75% [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT01354093 | Paul S. Bernstein|University of Utah |
Idiopathic Juxtafoveal Telangiectasia
|
November 2011 | |
| NCT00763659 | University of Jena |
Age Related Maculopathy
|
May 2008 | Not Applicable |
| NCT03959592 | Felipe Medeiros, MD|Heidelberg Engineering GmbH|MacuHealth LP|Industrial Orgánica S.A. de C.V.|Duke University |
Glaucoma
|
August 21, 2019 | Phase 1|Phase 2 |
| NCT01648660 | University of Jena |
Age Related Maculopathy
|
May 2009 | Not Applicable |
| NCT00909090 | University of Georgia|DSM Nutritional Products, Inc. |
Vision, Entoptic
|
May 2009 | Not Applicable |
| NCT05232409 | Valley Health System |
Cancer Metastatic|Metastatic Solid Tumor
|
March 2022 | Phase 1 |
| NCT01528605 | Peking University |
Age-related Macular Degeneration
|
June 2010 | Not Applicable |
| NCT03983525 | University of California, Davis |
Macular Pigment Optical Density
|
June 10, 2019 | Not Applicable |
| NCT00527553 | Maastricht University Medical Center|SenterNovem|Newtricious BV|Globus Ei BV |
Age-related Macular Degeneration
|
October 2007 | Not Applicable |
| NCT02017418 | University of Georgia|ZeaVision, LLC |
Behavior and Behavior Mechanisms
|
February 2012 | Not Applicable |
| NCT01627977 | Federal University of São Paulo |
Epiretinal Membrane|Macular Hole|Proliferative Diabetic Retinopathy
|
October 2012 | Phase 3 |
| NCT01404845 | Affordance|Drescode |
Exudative Age-related Macular Degeneration
|
September 2011 | Not Applicable |
| NCT02113254 | University Hospital, Bordeaux|Vilmorin & Cie |
Age Macular Degeneration
|
February 2014 | Not Applicable |
| NCT01048476 | Peking University |
Age-related Macular Degeneration
|
September 2009 | Phase 1|Phase 2 |
| NCT00564902 | Chrysantis, Inc.|Kowa Company, Ltd.|IMAGE TECHNOLOGIES INC. |
Age Related Macular Degeneration|Cognition Disorders
|
November 2007 | Not Applicable |
| NCT02200263 | Johns Hopkins University|Clark Charitable Foundation Inc. |
Ocular Albinism (OA)|Oculocutaneous Albinism (OCA)
|
November 2014 | Not Applicable |
Appearance
Solid
Source
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, protect from light
* The compound is unstable in solutions, freshly prepared is recommended.
Solvent & Solubility
THF : ≥ 10 mg/mL ( 17.58 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.7579 mL | 8.7894 mL | 17.5787 mL |
| 5 mM | 0.3516 mL | 1.7579 mL | 3.5157 mL |
| 10 mM | 0.1758 mL | 0.8789 mL | 1.7579 mL |
References
- [1] Bone RA, et al. Distribution of lutein and zeaxanthin stereoisomers in the human retina. Exp Eye Res. 1997 Feb;64(2):211-8.
- [2] Elbaz-Hayoun S, et al. Evaluation of antioxidant treatments for the modulation of macrophage function in the context of retinal degeneration. Mol Vis. 2019 Sep 5;25:479-488.
- [3] Krinsky NI, et al. Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye.Annu Rev Nutr. 2003;23:171-201.
Synonyms