[CAS NO. 1443763-60-7] Empesertib
PRODUCTS SPECIFICATIONS [1443763-60-7]
DESCRIPTION [1443763-60-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 559.61 |
| Molecular Formula | C29H26FN5O4S |
| SMILES | FC1=CC=C([C@@H](C)C(NC2=CC=C(C3=CN4N=C(NC5=CC=C(S(C)(=O)=O)C=C5OC)N=C4C=C3)C=C2)=O)C=C1 |
1 Publications Citing Use of MCE
Summary
Empesertib (BAY 1161909) is a potent Mps1 inhibitor, with an IC 50 of < 1 nM.
IC50 & Target
|
Mps1 1 nM (IC 50 ) |
In Vitro
BAY 1161909 is a potent Mps1 inhibitor, with an IC 50 of < 1 nM. BAY 1161909 also shows anti-tumor effect, suppressing the proliferation of Hela cells, with an IC 50 of < 400 nM [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT02138812 | Bayer |
Medical Oncology
|
May 9, 2014 | Phase 1 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 35 mg/mL ( 62.54 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.7870 mL | 8.9348 mL | 17.8696 mL |
| 5 mM | 0.3574 mL | 1.7870 mL | 3.5739 mL |
| 10 mM | 0.1787 mL | 0.8935 mL | 1.7870 mL |
References