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[CAS NO. 1446-61-3] Leelamine

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Catalog:	HY-W005629
Brand:	MCE
CAS:	1446-61-3

Overview

MDL	-
Molecular Weight	285.47
Molecular Formula	C20H31N
SMILES	NC[C@]1(C)CCC[C@]2(C)C3=C(CC[C@@]12[H])C=C(C(C)C)C=C3

For research use only. We do not sell to patients.

Summary

Leelamine is a weak agonist of cannabinoid receptors CB1 and CB2 . Leelamine also inhibits pyruvate dehydrogenase kinases (PDKs) . Leelamine exhibits anti-tumor activity ^[1] .

IC50 & Target

CB1

CB2

Appearance

<44.5°C Solid,>44.5°C Liquid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 350.30 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5030 mL	17.5150 mL	35.0299 mL
5 mM	0.7006 mL	3.5030 mL	7.0060 mL
10 mM	0.3503 mL	1.7515 mL	3.5030 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (8.76 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (8.76 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (8.76 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Merarchi M, et, al. A Brief Overview of the Antitumoral Actions of Leelamine. Biomedicines. 2019 Jul 19;7(3):53.
[2] Kuzu OF, Gowda R, Sharma A, Robertson GP. Leelamine mediates cancer cell death through inhibition of intracellular cholesterol transport. Mol Cancer Ther. 2014;13(7):1690-1703.

Synonyms

1-Phenanthrenemethanamine, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-, (1R,4aS,10aR)-

Podocarpa-8,11,13-trien-15-amine, 13-isopropyl-

1-Phenanthrenemethanamine, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-, [1R-(1α,4aβ,10aα)]-

Abietylamine, dehydro-

(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine

Dehydroabietylamine

NSC 2955

(+)-Dehydroabiethylamine

Leelamine

Dehydroabietic amine

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