[CAS NO. 144779-91-9] R-87366

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Catalog:	HY-19232
Brand:	MCE
CAS:	144779-91-9

Overview

MDL	-
Molecular Weight	617.70
Molecular Formula	C32H39N7O6
SMILES	O=C(N(CCC1)[C@@H]1C(NC(C)(C)C)=O)[C@@H](O)[C@@H](NC([C@H](CC(N)=O)NC(C2=CN=C3C(C=CC=C3)=N2)=O)=O)CC4=CC=CC=C4

For research use only. We do not sell to patients.

Summary

R-87366 is a water-soluble human immunodeficiency virus (HIV) protease inhibitor. R-87366 has potent inhibitory for HIV protease with a K _i value of 11 nM. R-87366 can be used for the research of anti-human immunodeficiency virus (HIV) ^[1] .

IC50 & Target

Ki: 11 nM (HIV protease) ^[1] .
IC90: 0.5 μM (HIV-1IIIB acutely infected cells) ^[1]

In Vitro

R-87366 has potent inhibitory for human immunodeficiency virus protease with a K _i value of 11 nM ^[1] .
R-87366 has activity for HIV-1IIIB acutely infected cells with an IC ₉₀ value of 0.5 μM ^[1] .
R-87366 has moderate water-solubility ^[1] .
R-87366 (0.25 μM; 0.5 μM) also has active in chronically infected Molt-4/HIV-1IIIB cells, and inhibits the proteolytic processing of p55 into p17 ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1] T Komai, et al. In vitro and ex vivo anti-human immunodeficiency virus (HIV) activities of a new water-soluble HIV protease inhibitor, R-87366, containing (2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid. Biol Pharm Bull. 1997 Feb;20(2):175-80.

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