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[CAS NO. 1449240-68-9] K145hydrochloride
| Ships within | Stock | Price | Qty | Total |
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| Catalog: | HY-15779A |
| Brand: | MCE |
| CAS: | 1449240-68-9 |
Overview
| MDL | MFCD28160629 |
|---|---|
| Molecular Weight | 384.92 |
| Molecular Formula | C18H25ClN2O3S |
| SMILES | O=C(N(CCN)C/1=O)SC1=C/CCC2=CC=C(OCCCC)C=C2.[H]Cl |
6 Publications Citing Use of MCE
Summary
In Vitro
K145 (0-10 µM; 24-72 hours; U937 cells) treatment significantly inhibits the growth of U937 cells in a concentration-dependent manner
[1]
.
K145 (10 µM; 24 hours; U937 cells) treatment significantly induces apoptosis in U937 cells
[1]
.
K145 (4-8 µM; 3 hours; U937 cells) treatment decreases the phosphorylation of ERK and Akt
[1]
.
Treatment with K145 (10 µM) causes a decrease of total cellular S1P without significant effects on ceramide levels
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | U937 cells |
| Concentration: | 0 µM, 4 µM, 6 µM, 8 µM, 10 µM |
| Incubation Time: | 24 hours, 48 hours, 72 hours |
| Result: | Significantly inhibited the growth of U937 cells in a concentration-dependent manner. |
Apoptosis Analysis [1]
| Cell Line: | U937 cells |
| Concentration: | 10 µM |
| Incubation Time: | 24 hours |
| Result: | Significantly induced apoptosis in U937 cells. |
Western Blot Analysis [1]
| Cell Line: | U937 cells |
| Concentration: | 4 µM, 8 µM |
| Incubation Time: | 3 hours |
| Result: | Phosphorylated ERK and Akt were decreased. |
In Vivo
K145 (50 mg/kg; oral gavage; daily; for 15 days; BALB/c-nu mice) treatment significantly inhibits the growth of U937 tumors in nude mice [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | BALB/c-nu mice injected with U937 cells [1] |
| Dosage: | 50 mg/kg |
| Administration: | Oral gavage; daily; for 15 days |
| Result: | Inhibited the growth of U937 tumors at 50 mg/kg dose and no apparent toxicity was observed. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 126.7 mg/mL ( 329.16 mM ; Need ultrasonic and warming)
DMSO : 50 mg/mL ( 129.90 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.5979 mL | 12.9897 mL | 25.9794 mL |
| 5 mM | 0.5196 mL | 2.5979 mL | 5.1959 mL |
| 10 mM | 0.2598 mL | 1.2990 mL | 2.5979 mL |
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