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[CAS NO. 1449685-96-4] DDR1-IN-1
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-13979 |
| Brand: | MCE |
| CAS: | 1449685-96-4 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 552.59 |
| Molecular Formula | C30H31F3N4O3 |
| SMILES | O=C(NC1=CC=C(C)C(OC2=CC3=C(NC(C3)=O)C=C2)=C1)C4=CC=C(CN5CCN(CC)CC5)C(C(F)(F)F)=C4 |
2 Publications Citing Use of MCE
Summary
IC50 & Target
IC50: 105 nM (DDR1) [1] .
In Vitro
DDR1-IN-1 effectively blocks collagen-induced DDR1 pY513 autophosphorylation in U2OS cells (EC 50 = 86.76 nM) with excellent selectivity over a panel of >380 kinases. DDR1-IN-1 inhibits DDR2-mediated MT1-MMP activation in human rheumatoid synovial fibroblasts (RASF) upon collagen stimulation (IC 50 < 2.5 μM) and enhances PI3K/mTOR inhibitor GSK2126458 antiproliferation efficacy in SNU-1040 colorectal cancer culture [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 180.97 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.8097 mL | 9.0483 mL | 18.0966 mL |
| 5 mM | 0.3619 mL | 1.8097 mL | 3.6193 mL |
| 10 mM | 0.1810 mL | 0.9048 mL | 1.8097 mL |
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