[CAS NO. 145307-34-2] A-77636 hydrochloride

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PRODUCTS SPECIFICATIONS [145307-34-2]

Catalog

HY-103416

Brand

MCE

CAS

145307-34-2

DESCRIPTION [145307-34-2]

Overview

MDL	-
Molecular Weight	365.89
Molecular Formula	C20H28ClNO3
SMILES	[H]Cl.NC[C@@H]1O[C@@H](CC2=C(O)C(O)=CC=C12)C34C[C@H](C5)C[C@H](C[C@H]5C4)C3

For research use only. We do not sell to patients.

Summary

A-77636 hydrochloride is a potent, orally active, selective and long acting dopamine D1 receptor agonist ( pK _i =7.40; K _i =39.8 nM) with antiparkinsonian activity. A-77636 hydrochloride is functionally inactive at dopamine D2 receptor ^[1] ^[2] .

In Vivo

A-77636 (0.1-1 mg/kg) exerts a suppressant effect on food intake, due principally to a reduction in meal size and duration ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male hooded rat ^[1]
Dosage:	0.1, 0.3 and 1.0 mg/kg
Administration:	S.c.
Result:	Exerted a suppressant effect on food intake, due principally to a reduction in meal size and duration.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

References

Synonyms

1H-2-Benzopyran-5,6-diol, 1-(aminomethyl)-3,4-dihydro-3-tricyclo[3.3.1.1^3,7]dec-1-yl-, hydrochloride (1:1), (1R,3S)-

1H-2-Benzopyran-5,6-diol, 1-(aminomethyl)-3,4-dihydro-3-tricyclo[3.3.1.1^3,7]dec-1-yl-, hydrochloride, (1R-cis)-

(1R,3S)-1-(Aminomethyl)-3,4-dihydro-3-tricyclo[3.3.1.1^3,7]dec-1-yl-1H-2-benzopyran-5,6-diol hydrochloride (1:1)

A 77636

A 77636 hydrochloride