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[CAS NO. 14660-91-4] Neoxanthin
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-N7523 |
| Brand: | MCE |
| CAS: | 14660-91-4 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 600.87 |
| Molecular Formula | C40H56O4 |
| SMILES | CC(/C=C/[C@](O1)(C(C)(C2)C)[C@]1(C[C@H]2O)C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=[C@@]=C([C@](O)(C3)C)C(C)(C[C@@H]3O)C |
Summary
In Vitro
Neoxanthin (20 μM; 72 h) treatment significantly reduces cell viability to 10.9% for PC-3 cells, 15.0% for DU 145 cells, and nearly zero for LNCaP cells, respectively
[1]
.
Neoxanthin strongly inhibits cell growth by suppressing DNA synthesis in C3H10T1/2 cells
[1]
.
In photosynthetic organisms, Neoxanthin is the essential component of both the photosystem I (PSI) and photosystem II (PSII) reaction centers of oxygenic photosynthetic apparatus
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
The gastrointestinal metabolism of Neoxanthin in mice is investigated. Two hours after the oral administration of Neoxanthin (40 nmol/mouse), Neoxanthin is found in the plasma and livers of mice. The concentrations of Neoxanthin is 13.6-9.0 nM in plasma, and 7.3 3.6 pmol/g in liver, respectively. (R/S)-Neochrome is also found in the small intestinal contents of Neoxanthin-administered mice [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Source
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
References
- [1] E Kotake-Nara, et al. Carotenoids Affect Proliferation of Human Prostate Cancer Cells. J Nutr. 2001 Dec;131(12):3303-6.
- [2] Ramesh Kumar Saini, et al. An Efficient One-Step Scheme for the Purification of Major Xanthophyll Carotenoids From Lettuce, and Assessment of Their Comparative Anticancer Potential. Food Chem. 2018 Nov 15;266:56-65.
- [3] Akira Asai, et al. An Epoxide-Furanoid Rearrangement of Spinach Neoxanthin Occurs in the Gastrointestinal Tract of Mice and in Vitro: Formation and Cytostatic Activity of Neochrome Stereoisomers. J Nutr. 2004 Sep;134(9):2237-43.
Synonyms
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