[CAS NO. 146949-21-5] Pocapavir
PRODUCTS SPECIFICATIONS [146949-21-5]
DESCRIPTION [146949-21-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 423.72 |
| Molecular Formula | C21H17Cl3O3 |
| SMILES | ClC1=C(OCC2=CC=C(COC3=CC=C(OC)C=C3Cl)C=C2)C(Cl)=CC=C1 |
3 Publications Citing Use of MCE
Summary
Pocapavir (SCH-48973) is an orally active capsid inhibitor. Pocapavir prevents virion uncoating upon entry into the cell. Pocapavir has antiviral activity against polioviruses. Pocapavir also inhibits enterovirus infections [1] .
In Vitro
Pocapavir belongs to a picornavirus antiviral mechanistic class called capsid inhibitors that block virus uncoating and viral RNA release into cells, which in turn prevents virus replication [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 236.00 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3600 mL | 11.8002 mL | 23.6005 mL |
| 5 mM | 0.4720 mL | 2.3600 mL | 4.7201 mL |
| 10 mM | 0.2360 mL | 1.1800 mL | 2.3600 mL |
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Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (5.90 mM); Clear solution