[CAS NO. 147362-57-0] Loviride
PRODUCTS SPECIFICATIONS [147362-57-0]
DESCRIPTION [147362-57-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 351.23 |
| Molecular Formula | C17H16Cl2N2O2 |
| SMILES | O=C(N)C(NC1=C(C(C)=O)C=CC(C)=C1)C2=C(Cl)C=CC=C2Cl |
Summary
Loviride (R 89439) is a non-nucleoside reverse transcriptase inhibitor ( NNRTI ), with an IC 50 of 0.3 µM for reverse transcriptase from HIV-1 . Loviride (R 89439) inhibits HIV-1 , HIV-2 and SIV replication in MT-4 cells [1] .
IC50 & Target
IC50: 0.3 µM (Reverse transcriptase) [1]
In Vitro
Loviride (0.01 µM) inhibits HIV-1(IIIB) replication in MT-4 cells, also inhibits HIV-2 and SIV, with EC 50 s of 85.5, 7.4 µM for HIV-2 (ROD), HIV-2 (EHO), and 11.4, 28.5, 57.0 µM for SIV (mac251), SIV (agm3), SIV (mndGB1), respectively [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 62.5 mg/mL ( 177.95 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.8471 mL | 14.2357 mL | 28.4714 mL |
| 5 mM | 0.5694 mL | 2.8471 mL | 5.6943 mL |
| 10 mM | 0.2847 mL | 1.4236 mL | 2.8471 mL |
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1.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 6.25 mg/mL (17.79 mM); Clear solution
Synonyms