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[CAS NO. 1477-57-2] Win 18446
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-W011094 |
| Brand: | MCE |
| CAS: | 1477-57-2 |
Overview
| MDL | MFCD00000841 |
|---|---|
| Molecular Weight | 366.11 |
| Molecular Formula | C12H20Cl4N2O2 |
| SMILES | O=C(NCCCCCCCCNC(C(Cl)Cl)=O)C(Cl)Cl |
1 Publications Citing Use of MCE
Summary
In Vitro
WIN 18446 (1 μM, 24 h) is able to suppress Stra8 expression in whole-testes cultures that contained both germ and somatic cells [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
RT-PCR [2]
| Cell Line: | Testes were collected from 2-dpp mice. |
| Concentration: | 1 μM. |
| Incubation Time: | 24 h. |
| Result: |
Results in a VAD-like phenotype in the testis.
Alone or in combination with ROL significantly reduced Stra8 expression. |
In Vivo
Win 18446 (200 mg/kg, Orally for 4, 8, and 16 weeks) significantly reduces intratesticular concentrations of retinoic acid, severely impaired spermatogenesis, and caused infertility [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Six-month-old male New Zealand white rabbits [1] . |
| Dosage: | 200 mg/kg. |
| Administration: | Orally for 4, 8, and 16 weeks. |
| Result: |
Resulted in marked suppression of testicular weight over time.
Dramatically suppressed spermatogenesis. Significantly reduces intratesticular concentrations of retinoic acid and Stra8 expression and very severely suppresses spermatogenesis and fertility. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL ( 273.14 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.7314 mL | 13.6571 mL | 27.3142 mL |
| 5 mM | 0.5463 mL | 2.7314 mL | 5.4628 mL |
| 10 mM | 0.2731 mL | 1.3657 mL | 2.7314 mL |
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1.
References
- [1] John K Amory, et al. Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis. J Androl. Jan-Feb 2011;32(1):111-9.
- [2] Cathryn A Hogarth, et al. Suppression of Stra8 expression in the mouse gonad by WIN 18,446. Biol Reprod. 2011 May;84(5):957-65.
Synonyms
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