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Catalog: | HY-15284 |
Brand: | MCE |
CAS: | 150322-43-3 |
MDL | MFCD09954140 |
---|---|
Molecular Weight | 373.44 |
Molecular Formula | C20H20FNO3S |
SMILES | FC1=CC=CC=C1C(C(C2CC2)=O)N3CCC4=C(C3)C=C(S4)OC(C)=O |
Prasugrel (PCR 4099), a thienopyridine and prodrug, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation [1] .
P2Y12 receptor [1]
In rat platelets, Prasugrel active metabolite inhibits in vitro platelet aggregation induced by adenosine ADP (10μM) with an IC
50
value of 1.8 μM
[2]
.
Prasugrel acts faster and is significantly more potent than Clopidogrel in vivo. Prasugrel is an inactive prodrug that requires metabolic processing in vivo to generate the active antiplatelet metabolite. Prasugrel is rapidly absorbed from the gut. After oral administration of standard-loading doses of 60 mg, maximum plasma levels of the active metabolite are achieved within 1 h, effective, maximum inhibition of platelet aggregation at 1-2 h
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
NCT Number | Sponsor | Condition | Start Date | Phase |
---|---|---|---|---|
NCT02285751 | Medical University of Vienna |
Critical Illness
|
November 2012 | Phase 2 |
NCT00357968 | Eli Lilly and Company|Daiichi Sankyo, Inc.|The TIMI Study Group |
Coronary Artery Disease
|
August 2006 | Phase 2 |
NCT01175200 | Ascopharm Groupe Novasco|Groupe Hospitalier Pitie-Salpetriere|Medco Health Solutions, Inc. |
Anti Platelet Effects
|
September 2010 | Not Applicable |
NCT02317198 | St. Antonius Hospital|UMC Utrecht|Leiden University Medical Center|Meander Medical Center|Medical Center Alkmaar|Isala|Gelre Hospitals|Gelderse Vallei Hospital|Medical Centre Leeuwarden|Rijnstate Hospital |
Non-ST-elevation Acute Coronary Syndrome|Unstable Angina|Non-ST-elevation Myocardial Infarction
|
June 2013 | Phase 4 |
NCT01765400 | University of Nebraska|Daiichi Sankyo, Inc.|Eli Lilly and Company |
Systolic Heart Failure
|
February 2013 | Phase 4 |
NCT01777503 | Arcispedale Santa Maria Nuova-IRCCS|ANMCO Italian Association of Hospital Cardiologist|Italian Society of Invasive Cardiology |
Acute Coronary Syndrome|Coronary Arteriosclerosis|Myocardial Ischemia|Cardiovascular Diseases
|
November 2012 | Phase 4 |
NCT01648790 | Eli Lilly and Company|Daiichi Sankyo, Inc. |
Healthy Volunteers
|
July 2012 | Phase 1 |
NCT02545933 | University of Florida|Merck Sharp & Dohme LLC |
Myocardial Infarction
|
February 2016 | Phase 4 |
NCT02808767 | Faculty Hospital Kralovske Vinohrady |
Myocardial Infarction|Angioplasty, Balloon, Coronary|Platelet Aggregation Inhibitors
|
January 2013 | Phase 4 |
NCT03027934 | CirQuest Labs, LLC |
Diabetes Mellitus
|
August 28, 2017 | Phase 4 |
NCT00827411 | Assistance Publique - Hôpitaux de Paris|Allies in Cardiovascular Trials Initiatives and Organized|Institut National de la Santé Et de la Recherche Médicale, France|Sanofi|Bristol-Myers Squibb|Medtronic|Cordis Corporation|Fondation de France|Diagnostica Stago|Boston Scientific Corporation |
Coronary Artery Disease|Acute Coronary Syndrome
|
January 2009 | Phase 4 |
NCT02422888 | Amsterdam UMC, location VUmc|Erasmus Medical Center|Hospital San Carlos, Madrid|Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)|University Medical Center Nijmegen |
Myocardial Infarction
|
May 2015 | Phase 4 |
NCT01456364 | Deutsches Herzzentrum Muenchen |
Coronary Heart Disease
|
September 2011 | Phase 4 |
NCT02487732 | Korea University Anam Hospital|AstraZeneca |
Acute Coronary Syndrome
|
July 2015 | Phase 4 |
NCT01015287 | Eli Lilly and Company|Daiichi Sankyo Co., Ltd. |
Acute Coronary Syndromes
|
December 2009 | Phase 3 |
NCT01790854 | David Antoniucci|A.R. CARD Onlus Foundation|Careggi Hospital |
Adverse Reaction to Antiplatelet Agent|Acute Coronary Syndrome
|
November 2012 | Phase 4 |
NCT03054207 | Jules Desmeules|University Hospital, Geneva |
Hiv
|
June 2015 | Phase 1 |
NCT00977938 | Baim Institute for Clinical Research|Abbott|Boston Scientific Corporation|Bristol-Myers Squibb|Sanofi-Synthelabo|Cordis Corporation|Eli Lilly and Company|Daiichi Sankyo, Inc.|Medtronic |
Coronary Artery Disease
|
October 2009 | Phase 4 |
NCT00385944 | Eli Lilly and Company|Daiichi Sankyo, Inc. |
Acute Coronary Syndrome
|
March 2007 | Phase 2 |
NCT03430661 | Idorsia Pharmaceuticals Ltd. |
Healthy
|
January 24, 2018 | Phase 1 |
NCT02065479 | University of Florida |
Coronary Artery Disease
|
March 2014 | Phase 4 |
NCT01339026 | Royal Brompton & Harefield NHS Foundation Trust|University Hospital Tuebingen |
Cardiovascular Disease|Acute Coronary Syndrome
|
February 2012 | Phase 4 |
NCT01327534 | Stiftung Institut fuer Herzinfarktforschung|Daiichi Sankyo, Inc. |
Myocardial Infarction|STEMI
|
May 2011 | Phase 3 |
NCT01538446 | Assistance Publique - Hôpitaux de Paris|Eli Lilly and Company|Daiichi Sankyo, Inc.|Allies in Cardiovascular Trials Initiatives and Organized|Accumetrics, Inc.|Stentys |
Acute Coronary Syndrome
|
March 2012 | Phase 4 |
NCT00059215 | Eli Lilly and Company |
Cardiovascular Diseases|Heart Diseases
|
April 2003 | Phase 2 |
NCT01597375 | Elliot Israel, MD|Brigham and Women´s Hospital |
Asthma, Aspirin-Induced|Aspirin Exacerbated Asthma
|
August 31, 2012 | Phase 2 |
NCT01641510 | Dong-A University |
Acute Coronary Syndromes
|
October 2013 | Phase 3 |
NCT03016611 | Sheba Medical Center |
Acute Coronary Syndrome|STEMI
|
February 2017 | Phase 4 |
NCT02016170 | University of Florida |
Coronary Artery Disease|Acute Coronary Syndrome
|
March 2014 | Not Applicable |
NCT01805570 | David Antoniucci|A.R. CARD Onlus Foundation|Careggi Hospital |
Myocardial Infarction
|
November 2012 | Phase 4 |
NCT01493999 | University of Pecs |
Acute Coronary Syndrome
|
September 2011 | Phase 4 |
NCT05086081 | Brigham and Women´s Hospital |
Acute Coronary Syndrome
|
October 10, 2020 | |
NCT01107925 | Eli Lilly and Company|Daiichi Sankyo Co., Ltd. |
Coronary Artery Disease
|
March 2010 | Phase 1 |
NCT02507323 | Yochai Birnbaum|AstraZeneca|Baylor College of Medicine |
Cardiovascular Disease
|
February 2016 | Phase 2 |
NCT01794000 | Eli Lilly and Company|Daiichi Sankyo, Inc. |
Sickle Cell Disease
|
April 2013 | Phase 3 |
NCT01109784 | University of Patras |
Coronary Artery Disease (CAD)|Acute Coronary Syndrome (ACS)
|
April 2010 | Phase 3 |
NCT00997503 | Boston Scientific Corporation|Eli Lilly and Company|Daiichi Sankyo, Inc. |
Coronary Artery Disease
|
December 2009 | |
NCT04237922 | Brigham and Women´s Hospital |
Antiplatelet
|
September 22, 2019 | |
NCT01360437 | University of Patras |
Coronary Artery Disease|Acute Coronary Syndrome
|
May 2011 | Phase 3 |
NCT01957540 | University of Patras |
Coronary Artery Disease|Endothelial Function
|
June 2014 | Phase 4 |
NCT01346800 | University Hospital, Geneva |
Healthy Volunteers
|
February 2011 | Phase 1 |
NCT01560780 | VA Office of Research and Development |
Coronary Artery Bypass
|
February 1, 2013 | Phase 3 |
NCT01452139 | Ottawa Heart Institute Research Corporation|Spartan Bioscience Inc. |
STEMI
|
September 2011 | Phase 2|Phase 3 |
NCT01465828 | Gennaro Sardella|University of Roma La Sapienza |
Acute Coronary Syndrome
|
October 2011 | Phase 3 |
NCT01979445 | The Medicines Company |
Coronary Artery Disease (CAD)
|
December 2, 2013 | Phase 2 |
NCT05223335 | Mayo Clinic |
Bleeding Complications
|
March 29, 2022 | Phase 4 |
NCT04734353 | Gyeongsang National University Hospital|U&I Corporation |
Coronary Artery Disease
|
January 15, 2020 | Phase 4 |
NCT01505790 | Assistance Publique Hopitaux De Marseille |
Acute Coronary Syndromes
|
July 2011 | Phase 3 |
NCT04668144 | University of Florida|Scott R. MacKenzie Foundation |
Coronary Artery Disease|Acute Coronary Syndrome
|
February 9, 2021 | Phase 4 |
NCT01463163 | University of Patras |
Platelet Reactivity
|
October 2011 | Phase 4 |
NCT05183178 | Vastra Gotaland Region|Region Skane|Region Halland|Region Gävleborg|Region Örebro County|Region Västerbotten|Jämtland County Council, Sweden |
Acute Coronary Syndrome
|
February 1, 2022 | Phase 4 |
NCT01591317 | Eli Lilly and Company |
Healthy Volunteers
|
March 2009 | Phase 1 |
NCT01959451 | LMU Klinikum |
Acute Coronary Syndrome
|
September 2013 | Phase 4 |
NCT02944123 | Dong-A University |
Acute Coronary Syndrome
|
September 2016 | Phase 3 |
NCT03469856 | Pedro A. Lemos|Imperial College London|Cardialysis B.V.|InCor Heart Institute |
Monotherapy After PCI
|
February 22, 2018 | Not Applicable |
NCT00699998 | Eli Lilly and Company|Daiichi Sankyo Co., Ltd.|Duke Clinical Research Institute |
Acute Coronary Syndrome
|
June 2008 | Phase 3 |
NCT01107899 | Eli Lilly and Company|Daiichi Sankyo Co., Ltd. |
Acute Coronary Syndromes
|
October 2009 | Phase 1 |
NCT01184300 | Ottawa Heart Institute Research Corporation|Spartan Bioscience Inc. |
Stable Coronary Artery Disease|Acute Coronary Syndrome|Percutaneous Coronary Intervention
|
August 2010 | Phase 2|Phase 3 |
NCT01700322 | Johannes Gutenberg University Mainz |
Coronary Artery Disease
|
August 2012 | Phase 4 |
NCT01642966 | University of Patras |
Acute Coronary Syndrome
|
September 2012 | Phase 4 |
NCT02193971 | Seoul National University Hospital|Boston Scientific Korea Co. Ltd|Dio|Terumo Corporation|Abbott |
Acute Coronary Syndrome
|
July 2014 | Phase 4 |
NCT01135667 | Lene Holmvang|Rigshospitalet, Denmark |
Coronary Artery Disease|Percutaneous Coronary Intervention|Acute Coronary Syndromes
|
September 2010 | Phase 4 |
NCT01106534 | Abbott Medical Devices|Baim Institute for Clinical Research|Bristol-Myers Squibb|Eli Lilly and Company|Daiichi Sankyo, Inc. |
Chronic Total Occlusion of Coronary Artery|Vascular Disease|Myocardial Ischemia|Coronary Artery Stenosis|Coronary Disease|Coronary Artery Disease|Coronary Restenosis
|
August 2009 | Phase 4 |
NCT03489863 | University of Florida|Scott R. MacKenzie Foundation |
Coronary Artery Disease
|
May 30, 2018 | Phase 4 |
NCT01852214 | University of Florida |
Diabetes Mellitus|Coronary Artery Disease
|
February 2013 | Not Applicable |
NCT01099566 | Medical University of Vienna |
Healthy Volunteers|Sepsis
|
November 2009 | Phase 4 |
NCT00954707 | Cordis Corporation |
Coronary Artery Disease
|
August 2009 | Phase 4 |
NCT03273075 | Medical University of Vienna |
Cardiopulmonary Arrest With Successful Resuscitation|ACS - Acute Coronary Syndrome|Hypothermia, Induced
|
September 2017 | Phase 4 |
NCT00642174 | Eli Lilly and Company|Daiichi Sankyo, Inc. |
Diabetes Mellitus|Coronary Artery Disease
|
April 2008 | Phase 2 |
NCT05247385 | University of Sao Paulo |
Coronary Artery Disease
|
March 20, 2017 | Phase 4 |
NCT01167023 | Eli Lilly and Company|Daiichi Sankyo, Inc. |
Sickle Cell Anemia
|
July 2010 | Phase 2 |
NCT03387826 | Attikon Hospital |
Myocardial Infarction|Diabetes Mellitus|Coronary Artery Disease|Renal Disease
|
January 11, 2018 | Phase 4 |
NCT01336348 | Università degli Studi di Ferrara |
ST Segment Elevation Myocardial Infarction
|
April 2010 | Phase 3 |
NCT01830543 | Janssen Scientific Affairs, LLC|Bayer |
Atrial Fibrillation|Percutaneous Coronary Intervention
|
May 10, 2013 | Phase 3 |
NCT05117866 | Meditrix Corp|Fujita Health University|Boston Scientific Japan K.K.|National University of Ireland, Galway, Ireland |
Chronic Coronary Syndrome|Non ST Segment Elevation Acute Coronary Syndrome
|
September 15, 2020 | Not Applicable |
NCT02548611 | LMU Klinikum |
Angina Pectoris
|
September 2015 | Phase 4 |
NCT02261922 | Hotel Dieu de France Hospital |
Antiplatelet Agents; Endothelial Function; Pleotropic Effects
|
October 2014 | Phase 4 |
NCT04981041 | Ludwig-Maximilians - University of Munich |
Acute Coronary Syndrome|Atrial Fibrillation
|
December 16, 2021 | Phase 4 |
NCT02587260 | Erasmus Medical Center|Covance |
Cardiovascular Diseases
|
December 17, 2015 | Phase 4 |
NCT01587651 | Daiichi Sankyo, Inc.|Eli Lilly and Company |
Coronary Artery Disease
|
March 2012 | Phase 4 |
NCT00910299 | Eli Lilly and Company|Daiichi Sankyo Co., Ltd. |
Coronary Artery Disease (CAD)
|
July 2009 | Phase 2 |
NCT00097591 | Eli Lilly and Company|Daiichi Sankyo, Inc. |
Coronary Arteriosclerosis|Acute Coronary Syndromes
|
November 2004 | Phase 3 |
NCT01789814 | Tufts Medical Center |
Coronary Artery Disease
|
July 2013 | Phase 4 |
NCT01852175 | University of Florida |
Coronary Artery Disease
|
January 2012 | Not Applicable |
NCT02075268 | Asan Medical Center |
Healthy
|
January 2014 | Phase 1 |
NCT01598337 | Prince Sultan Cardiac Center, Adult Cardiology Department. |
Coronary Artery Disease
|
April 2011 | Phase 3 |
NCT01612884 | Indiana University |
Thrombosis|Coronary Artery Disease
|
August 2011 | Phase 4 |
NCT01823185 | Imam Abdulrahman Bin Faisal University|King Fahad Armed Forces Hospital|Dammam Central Hospital |
Coronary Artery Disease|Myocardial Infarction|Heart Disease|Vascular Disease|Angina Pectoris|Cardiovascular Disease|Ischemia|Infarction|Embolism|Thrombosis|Chest Pain
|
March 2013 | Phase 4 |
NCT01304472 | University of Patras |
Coronary Artery Disease (CAD)
|
February 2011 | Phase 3 |
NCT01852019 | The Medicines Company |
Coronary Artery Disease
|
June 2013 | Phase 2 |
NCT01944800 | Deutsches Herzzentrum Muenchen|Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) |
Acute Coronary Syndrome (ACS)
|
September 15, 2013 | Phase 4 |
NCT03581409 | Seoul National University Hospital|Seoul National University Bundang Hospital |
Aneurysm, Cerebral|Endovascular Procedures
|
October 24, 2018 | Phase 4 |
NCT01774838 | University of Cologne |
Acute Coronary Syndrome|Unstable Angina
|
October 2014 | Phase 3 |
NCT01155765 | University of Patras |
Hemodialysis|Chronic Renal Failure
|
May 2010 | Phase 3 |
NCT01178099 | Eli Lilly and Company|Daiichi Sankyo Co., Ltd. |
Anemia, Sickle Cell
|
July 2010 | Phase 1 |
NCT00356135 | Eli Lilly and Company|Daiichi Sankyo, Inc. |
Coronary Arteriosclerosis|Acute Coronary Syndrome
|
July 2006 | Phase 2 |
NCT01510171 | Careggi Hospital |
ST-segment Elevation Myocardial Infarction
|
January 2012 | Phase 4 |
NCT02212028 | University of Florida |
Coronary Artery Disease
|
October 2014 | Phase 4 |
NCT01642940 | University of Patras |
Coronary Artery Disease|Acute Coronary Syndrome
|
June 2012 | Phase 4 |
NCT00830960 | Eli Lilly and Company|Daiichi Sankyo Co., Ltd. |
Acute Coronary Syndrome
|
February 2009 | Phase 3 |
NCT02070159 | Dong-A University |
Coronary Artery Disease
|
December 2011 | Phase 3 |
NCT03454841 | Collegium Medicum w Bydgoszczy |
Acute Myocardial Infarction
|
February 26, 2018 | |
NCT01365221 | Medstar Health Research Institute |
Acute Coronary Syndrome
|
October 2010 | Phase 4 |
NCT02243137 | David Vivas|St Carlos Hospital, Madrid, Spain|Fundacion Investigacion Interhospitalaria Cardiovascular |
Adverse Effect of Antithrombotic Drugs
|
May 2013 | Phase 1 |
NCT01201772 | University of Florida |
Coronary Artery Disease
|
August 2010 | Phase 4 |
NCT01543932 | University of Roma La Sapienza |
Coronary Artery Disease
|
July 2012 | Phase 3 |
NCT01463150 | University of Patras |
Platelet Reactivity
|
October 2011 | Phase 4 |
NCT02075125 | Dong-A University |
ST-Segment Elevation Myocardial Infarction
|
January 2014 | Phase 3 |
NCT01869309 | LifeBridge Health|AstraZeneca |
Coronary Artery Disease
|
January 2014 | Phase 4 |
NCT01835353 | University of Patras |
Platelet Reactivity
|
June 2012 | Phase 3 |
NCT00976092 | Deutsches Herzzentrum Muenchen |
Myocardial Infarction
|
September 2009 | Phase 4 |
NCT01531114 | Gennaro Sardella|University of Roma La Sapienza |
ST-Elevation Myocardial Infarction
|
May 2013 | Phase 3 |
NCT01338909 | University of Patras |
Myocardial Infarction
|
April 2011 | Phase 3 |
NCT02866175 | Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company|Daiichi Sankyo, Inc. |
Atrial Fibrillation
|
February 24, 2017 | Phase 3 |
NCT01260584 | Daiichi Sankyo, Inc. |
Coronary Artery Disease
|
November 2010 | Phase 4 |
NCT04006288 | University of Florida|Janssen, LP |
Coronary Artery Disease
|
September 6, 2019 | Phase 4 |
NCT05491200 | Research Maatschap Cardiologen Rotterdam Zuid|Abbott Medical Devices |
ST Elevated Myocardial Infarction|Dual Antiplatelet Therapy
|
July 22, 2022 | Phase 4 |
NCT01305369 | University of Milan |
Chronic Asthma
|
March 2011 | Phase 4 |
NCT01452152 | University of Maryland, Baltimore|National Heart, Lung, and Blood Institute (NHLBI) |
Cardiovascular Diseases|Acute Coronary Syndrome
|
February 2012 | Phase 4 |
NCT02978040 | University Hospital Inselspital, Berne |
Coronary Artery Disease|STEMI - ST Elevation Myocardial Infarction
|
July 4, 2017 | Phase 4 |
NCT02108808 | University of Patras |
Fractional Flow Reserve
|
April 2014 | Phase 4 |
NCT03672097 | Daiichi Sankyo Taiwan Ltd., a Daiichi Sankyo Company|Daiichi Sankyo, Inc. |
Acute Coronary Syndrome (ACS)
|
October 16, 2018 | Phase 4 |
NCT01014624 | Daiichi Sankyo, Inc. |
Coronary Artery Disease
|
February 2010 | Phase 4 |
NCT01778842 | Gennaro Sardella|University of Roma La Sapienza |
Coronary Artery Disease
|
March 2013 | Phase 3 |
NCT01515345 | Kaiser Franz Josef Hospital |
Platelet Inhibition|Coronary Stent Implantation
|
July 2011 | Phase 3 |
NCT01476696 | Eli Lilly and Company|Daiichi Sankyo, Inc. |
Sickle Cell Disease
|
November 2011 | Phase 2 |
NCT03296540 | Maasstad Hospital|MicroPort Orthopedics Inc.|Daiichi Sankyo, Inc.|Research Maatschap Cardiologen Rotterdam Zuid |
Cardiovascular Diseases
|
November 28, 2017 | Phase 4 |
NCT03435133 | AORTICA Group |
ST Elevation Myocardial Infarction
|
November 23, 2015 | Not Applicable |
NCT01107912 | Eli Lilly and Company|Daiichi Sankyo Co., Ltd. |
Coronary Artery Disease
|
March 2010 | Phase 1 |
NCT01951001 | Gyeongsang National University Hospital |
Acute Coronary Syndrome|Platelet Thrombus|Bleeding
|
July 2013 | Phase 4 |
NCT01430091 | Eli Lilly and Company |
Sickle Cell Disease
|
September 2011 | Phase 1 |
NCT04445623 | Azienda Ospedaliera Universitaria Integrata Verona|University of Milan |
COVID19|Thrombosis
|
July 2020 | Phase 3 |
NCT02215993 | Federal University of São Paulo |
Acute Coronary Syndrome|Platelet Function
|
July 2013 | Phase 4 |
NCT01609647 | Dong-A University |
Acute Coronary Syndrome
|
September 2012 | Phase 3 |
NCT02376283 | The Royal Wolverhampton Hospitals NHS Trust |
Heart Attack
|
March 9, 2015 | Phase 4 |
NCT05359224 | Yonsei University|Severance Hospital|Gangnam Severance Hospital|Bucheon St. Mary´s Hospital|International St. Mary´s Hospital|Ewha Woman´s University Seoul Hospital |
Intracranial Aneurysm
|
June 13, 2022 | Phase 4 |
NCT01115738 | Eli Lilly and Company |
Acute Coronary Syndrome
|
May 2010 | Phase 2 |
NCT04766437 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) |
Non ST Segment Elevation Acute Coronary Syndrome
|
February 19, 2021 | Phase 2 |
NCT02032303 | Azienda Policlinico Umberto I |
Acute Coronary Syndrome|Non ST Elevation Myocardial Infarction|ST Elevation Myocardial Infarction|Unstable Angina
|
February 2014 | Phase 4 |
Solid
Room temperature in continental US; may vary elsewhere.
Powder | -20°C | 3 years |
---|---|---|
4°C | 2 years | |
In solvent | -80°C | 6 months |
-20°C | 1 month |
DMSO : 100 mg/mL ( 267.78 mM ; Need ultrasonic)
H 2 O : < 0.1 mg/mL (insoluble)
Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
---|
1 mM | 2.6778 mL | 13.3890 mL | 26.7781 mL |
5 mM | 0.5356 mL | 2.6778 mL | 5.3556 mL |
10 mM | 0.2678 mL | 1.3389 mL | 2.6778 mL |
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