[CAS NO. 150436-68-3] Lactisole

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PRODUCTS SPECIFICATIONS [150436-68-3]

Catalog

HY-W030796A

Brand

MCE

CAS

150436-68-3

DESCRIPTION [150436-68-3]

Overview

MDL	MFCD07783974
Molecular Weight	218.18
Molecular Formula	C10H11NaO4
SMILES	COC1=CC=C(C=C1)OC(C(O[Na])=O)C

For research use only. We do not sell to patients.

Summary

Lactisole is a canonical antagonist of sweet taste receptor , selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole inhibits insulin secretion induced by glucose in mouse islets ^[1] ^[2] .

IC50 & Target

T1R3 ^[1]

In Vitro

Lactisole (3-10 mM; 48 h) does-dependently inhibits insulin secretion induced by Acesulfame-K, Sucralose (HY-N0614) and Glycyrrhizin (HY-N0184) in mouse pancreatic β-cells MIN6 (IC ₅₀ ~4 mM) ^[1] .
Lactisole (5 mM; 48 h) attenuates the elevation of cytoplasmic Ca ²⁺ concentration ([Ca ²⁺ ] _c ) evoked by sucralose and acesulfame-K without affecting the elevation of intracellular cAMP concentration ([cAMP] _c ) ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Synonyms

Propanoic acid, 2-(4-methoxyphenoxy)-, sodium salt (1:1)

Propanoic acid, 2-(4-methoxyphenoxy)-, sodium salt, (±)-

Propanoic acid, 2-(4-methoxyphenoxy)-, sodium salt

Sodium 2-(4-Methoxyphenoxy)propionate

Lactisole

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