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[CAS NO. 152121-47-6] Adezmapimod

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Catalog:	HY-10256
Brand:	MCE
CAS:	152121-47-6

Overview

MDL	MFCD00922198
Molecular Weight	377.43
Molecular Formula	C21H16FN3OS
SMILES	O=S(C1=CC=C(C2=NC(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)N2)C=C1)C

For research use only. We do not sell to patients.

340 Publications Citing Use of MCE

[1]Cell Res. 2020 Jul;30(7):574-589.
[2]Mol Cell. 2020 Jan 2;77(1):95-107.e5.
[3]Nat Metab. 2021 Oct 18.
[4]Signal Transduct Target Ther. 2022 Jul 11;7(1):222.
[5]Signal Transduct Target Ther. 2020 Aug 25;5(1):163.
[6]Sci Immunol. 2022 Jan 21;7(67):eabj5501.
[7]Nat Commun. 2018 Apr 30;9(1):1723.
[8]Genome Biol. 2023 Feb 1;24(1):20.
[9]Cell Death Differ. 2020 Jun;27(6):1938-1951.
[10]Cell Death Differ. 2019 Nov;26(11):2386-2399.
[11]Cell Death Differ. 2017 Mar;24(3):492-499.
[12]Biomaterials. 2018 Aug;175:19-29.
[13]Protein Cell. 2019 Mar;10(3):161-177.
[14]Redox Biol. 2023, 102594.
[15]Redox Biol. 30 August 2022, 102452.
[16]J Immunother Cancer. 2019 Jul 12;7(1):178.
[17]J Immunother Cancer. 2018 Dec 18;6(1):151.
[18]Autophagy. 2021 Nov;17(11):3592-3606.
[19]Autophagy. 2020 Aug;16(8):1413-1435.
[20]Cancer Res. (2022) 82 (10): 1991-2002.
[21]Chem Sci. 2018 Jan 31;9(10):2674-2689.
[22]EMBO Mol Med. 2022 Dec 13;e16373.
[23]J Cell Biol. 2021 Feb 1;220(2):e201911025.
[24]Cell Mol Immunol. 2023 Jan 5.
[25]Cell Mol Immunol. 2022 Nov;19(11):1263-1278.
[26]Npg Asia Mater. (2019) 11:38
[27]Cell Rep. 2022 Dec 27;41(13):111891.
[28]Cell Rep. 2022 Mar 15;38(11):110520.
[29]Cell Rep. 2020 Jan 14;30(2):497-509.e4.
[30]Oncogene. 2022 Jan 7.
[31]Oncogene. 2017 Apr;36(15):2095-2104.
[32]Br J Pharmacol. 2020 Nov;177(22):5046-5062.
[33]Br J Pharmacol. 2018 Dec;175(23):4338-4352.
[34]Environ Int. 2020 Oct;143:105949.
[35]EMBO Rep. 2021 Jul 5;22(7):e51678.
[36]Cancer Lett. 2017 Feb 16;393:22-32.
[37]Aging Cell. 2022 Jun 17;e13659.
[38]Aging Cell. 2020 Oct;19(10):e13217.
[39]Carbohydr Polym. 2019 Dec 1;225:115223.
[40]J Invest Dermatol. 2022 Apr 11;S0022-202X(22)00272-X.
[41]J Invest Dermatol. 2021 Aug 3;S0022-202X(21)01670-5.
[42]J Invest Dermatol. 2019 Dec;139(12):2488-2496.e4.
[43]Haematologica. 2020 Jan;105(1):124-135.
[44]Acta Pharm Sin B. 5 September 2022.
[45]Elife. 2016 Apr 11;5:e14087.
[46]PLoS Biol. 2018 May 11;16(5):e2004225.
[47]J Exp Clin Cancer Res. 2022 Dec 29;41(1):364.
[48]J Exp Clin Cancer Res. 2022 Sep 16;41(1):275.
[49]Environ Pollut. 2022 Oct 1;120234.
[50]Environ Pollut. 2021 Jan 1;268(Pt B):115748.
[51]Environ Pollut. 2020 Jan;256:113375.
[52]J Nanobiotechnology. 2022 Mar 27;20(1):162.
[53]Cell Mol Life Sci. 2018 Jul;75(14):2627-2641.
[54]Cell Death Dis. 2022 Nov 23;13(11):987.
[55]Cell Death Dis. 2022 Oct 8;13(10):860.
[56]Cell Death Dis. 2022 Jul 15;13(7):615.
[57]Cell Death Dis. 2021 Nov 27;12(12):1113.
[58]Cell Death Dis. 2021 Jun 2;12(6):570.
[59]Cell Death Dis. 2021 Jun 7;12(6):582.
[60]Cell Death Dis. 2019 Jul 8;10(7):520.
[61]Cell Death Dis. 2019 Mar 15;10(4):255.
[62]Cell Death Dis. 2016 Jun 23;7(6):e2273.
[63]Curr Res Nutr Food Sci. 2023 Jan.
[64]Free Radic Biol Med. 2021 Dec;177:247-259.
[65]Free Radic Biol Med. 2019 Nov 1;143:275-287.
[66]Free Radic Biol Med. 2017 Nov;112:49-59.
[67]Stem Cells. 2022 Jun 30;sxac046.
[68]Stem Cells. 2022 May 27;40(5):508-522.
[69]Stem Cells. 2020 Jan;38(1):134-145.
[70]Pharmacol Res. 2018 Jul;133:218-235.
[71]Int J Radiat Oncol Biol Phys. 2022 Dec 16;S0360-3016(22)03519-2.
[72]J Neuroinflammation. 2022 Nov 24;19(1):283.
[73]J Neuroinflammation. 2020 Oct 28;17(1):321.
[74]J Neuroinflammation. 2018 Jun 15;15(1):184.
[75]Chemosphere. 2020 Oct;256:127038.
[76]Cell Prolif. 2021 Jan;54(1):e12933.
[77]Cell Prolif. 2019 Nov;52(6):e12691.
[78]Aging (Albany NY). 2022 Aug 5;14(15):6149-6168.
[79]Cancer Commun (Lond). 2021 Jan 1.
[80]J Cell Physiol. 2020 Oct;235(10):6563-6573.
[81]J Cell Physiol. 2019 Dec;234(12):23302-23314.
[82]Acta Physiol (Oxf). 2018 Feb;222(2).
[83]J Clin Endocrinol Metab. 2021 Jan 23;106(2):337-350.
[84]Mol Nutr Food Res. 2019 Dec;63(24):e1900601.
[85]J Eur Acad Dermatol Venereol. 2020 Apr;34(4):862-872.
[86]Front Cell Dev Biol. 2021 Jun 18;9:659389.
[87]Front Cell Dev Biol. 2021 Feb 11;9:570451.
[88]Int J Biol Macromol. 2022 Dec 12;227:45-57.
[89]Int J Biol Macromol. 2020 May 1;150:261-280.
[90]Int J Cancer. 2018 Aug 1;143(3):645-656.
[91]Stem Cell Res Ther. 2022 Jan 21;13(1):22.
[92]Stem Cell Res Ther. 2021 May 20;12(1):295.
[93]Hum Mol Genet. 2017 Sep 15;26(18):3553-3563.
[94]Front Immunol. 2021 Jul 7;12:692286.
[95]Front Immunol. 2021 Jul 28;12:688294.
[96]Front Immunol. 2021 Apr 1;12:584097.
[97]Front Immunol. 2018 Dec 7;9:2854.
[98]Front Immunol. 2018 Jun 5;9:1225.
[99]Front Immunol. 2017 Oct 10;8:1278.
[100]Oxid Med Cell Longev. 22 Jun 2022.
[101]Oxid Med Cell Longev. 10 Mar 2022.
[102]Oxid Med Cell Longev. 2017;2017:6175841.
[103]Acta Pharmacol Sin. 2022 Feb 7.
[104]Acta Pharmacol Sin. 2017 Aug;38(8):1120-1128.
[105]Antioxidants (Basel). 2022 Mar 31;11(4):682.
[106]Antioxidants. 2021 Jun 29;10(7):1049.
[107]Antioxidants. 2021, 10(3), 443.
[108]FASEB J. 2020 Nov;34(11):14892-14904.
[109]FASEB J. 2020 Jun;34(6):8442-8458.
[110]FASEB J. 2019 Feb;33(2):2435-2450.
[111]J Inflamm Res. 2021 Mar 23;14:1007-1017.
[112]Nanotoxicology. 2020 Jun;14(5):667-682.
[113]Nitric Oxide. 8 October 2022.
[114]Ecotoxicol Environ Saf. 2020 Mar 1;190:110133.
[115]Int J Biol Sci. 2022 May 1;18(8):3167-3177.
[116]Front Oncol. 2020 Sep 30;10:523577.
[117]Aging. 2021 May 6;13(10):13788-13806.
[118]Aging. 2021 May 11;13(9):12780-12799.
[119]Aging. 2020 Nov 20;12(23):24208-24218.
[120]Biomedicines. 2020 Nov 9;8(11):485.
[121]Food Chem Toxicol. 2022: 113550.
[122]Food Chem Toxicol. 2020 Dec 28;148:111925.
[123]Int J Mol Sci. 2022 Nov 25;23(23):14730.
[124]Int J Mol Sci. 2022, 23(23), 14730
[125]Int J Mol Sci. 2022, 23(22), 14141
[126]Int J Mol Sci. 2022, 23(20), 12219.
[127]Int J Mol Sci. 2022 Mar 25;23(7):3589.
[128]Biomed Pharmacother. 2020 Sep;129:110384.
[129]Biomed Pharmacother. 2020 Mar;123:109752.
[130]Biomed Pharmacother. 2020 Jan;121:109304.
[131]Biomed Pharmacother. 2019 Dec;120:109489.
[132]Biomed Pharmacother. 2018 Oct 3;108:1294-1302.
[133]Apoptosis. 2021 Feb 7.
[134]J Cell Mol Med. 2020 Sep;24(18):10935-10945.
[135]J Cell Mol Med. 2020 Aug;24(16):9300-9312.
[136]J Cell Mol Med. 2019 May;23(5):3357-3368.
[137]J Cell Mol Med. 2018 Nov;22(11):5450-5467.
[138]Am J Physiol Cell Physiol. 2022 May 18.
[139]Am J Physiol Cell Physiol. 2018 Aug 1;315(2):C225-C235.
[140]Cells. 2022 Feb 18;11(4):723.
[141]Biochim Biophys Acta Mol Basis Dis. 2022 Feb 15;1868(5):166369.
[142]Cell Commun Signal. 2021 Oct 11;19(1):103.
[143]Aquat Toxicol. 2018 Jun;199:116-126.
[144]Phytomedicine. 5 January 2022, 153928.
[145]Phytomedicine. 2021, 153479.
[146]Phytomedicine. 2020 Nov;78:153306.
[147]Phytomedicine. 2020 May 24;75:153247.
[148]Phytomedicine. 2020 Mar;68:153146.
[149]Phytomedicine. 2018 Mar 15;42:152-163.
[150]J Biol Chem. 2019 Apr 19;294(16):6531-6549.
[151]J Cell Biochem. 2018 Dec 2.
[152]J Cell Biochem. 2018 Nov;119(10):8450-8459.
[153]Front Pharmacol. 2021 May 18;12:644116.
[154]Front Pharmacol. 2021 Apr 30;12:644886.
[155]J Agric Food Chem. 2023 Feb 8.
[156]J Agric Food Chem. 2022 Apr 13;70(14):4328-4341.
[157]J Agric Food Chem. 2018 Jun 27;66(25):6317-6325.
[158]Food Funct. 2021 Mar 9.
[159]Commun Biol. 2022 Jul 22;5(1):726.
[160]Acs Biomater Sci Eng. 2021 Jun 10.
[161]J Mol Cell Cardiol. 2015 Dec;89(Pt B):268-79.
[162]J Transl Med. 2019 Oct 4;17(1):335.
[163]Front Cell Infect Microbiol. 2019 Jul 15;9:253.
[164]Mol Ther Oncolytics. 5 August 2022.
[165]Cell Death Discov. 2019 Aug 5;5:125.
[166]Biochim Biophys Acta Mol Cell Res. 2021 Jun 17;119083.
[167]Antiviral Res. 2022 Nov 10;105463.
[168]Toxicology. 2021 Feb 13;152721.
[169]Phytother Res. 2022 Oct 17.
[170]Vaccines. 2019 Dec 14;7(4):216.
[171]J Proteome Res. 2021 Apr 2.
[172]CNS Neurosci Ther. 2020 Sep;26(9):913-924.
[173]Sci Rep. 2022 Feb 23;12(1):3053.
[174]Sci Rep. 2017 Oct 19;7(1):13571.
[175]Cell Signal. 2021 Jun 2;85:110060.
[176]Cell Signal. 2020 Mar;67:109522.
[177]Cell Signal. 2019 Feb;54:17-26.
[178]Cell Signal. 2016 Feb;28(2):81-93.
[179]Int Immunopharmacol. 2022 Feb 28;107:108643.
[180]Int Immunopharmacol. 2021 Oct 26;101(Pt A):108264.
[181]Int Immunopharmacol. 2020 Nov;88:106949.
[182]Int Immunopharmacol. 2020 Nov;88:106823.
[183]Int Immunopharmacol. 2020 Jun;83:106473.
[184]Int Immunopharmacol. 2019 Dec;77:105940.
[185]Int Immunopharmacol. 2019 Jul;72:252-257.
[186]Respir Res. 2022 Jan 11;23(1):6.
[187]Respir Res. 2021 Aug 3;22(1):216.
[188]Neurochem Int. 12 November 2021, 105221.
[189]Mol Cell Endocrinol. 2019 Apr 5;485:35-43.
[190]Mol Cell Endocrinol. 2018 Jul 15;470:38-47.
[191]Viruses. 2022, 14(7), 1465.
[192]Viruses. 2022, 14(7), 1485.
[193]Mediators Inflamm. 2020 Nov 3;2020:8925973.
[194]J Periodontol. 2021 Sep 17.
[195]J Periodontol. 2020 Jan 16.
[196]Chem Biol Interact. 2021 Sep 8;348:109634.
[197]J Funct Foods. 2019, 103562.
[198]J Ethnopharmacol. 2021 Jul 24;114414.
[199]Int J Biochem Cell Biol. 2021, 106036.
[200]Int J Biochem Cell Biol. 2021, 106003.
[201]Life Sci. 2021 Dec 21;120258.
[202]Life Sci. 2020 Nov 15;261:118465.
[203]Life Sci. 2020 Apr 1;246:117396.
[204]Front Endocrinol. 2021 Mar 12;12:629554.
[205]Mol Immunol. 2021 Jan 15;S0161-5890(20)30590-3.
[206]Mol Immunol. 2018 Sep 26;103:133-143.
[207]Mol Immunol. 2017 Jul;87:161-170.
[208]Toxins. 2022 Jan 1;14(1):29.
[209]Toxins. 2021 Jun 13;13(6):422.
[210]Invest Ophthalmol Vis Sci. 2020 Jul 1;61(8):28.
[211]Cell Microbiol. 2019 Sep;21(9):e13064.
[212]Arch Biochem Biophys. 2022: 109486.
[213]Am J Transl Res. 2020 Jul 15;12(7):3577-3595.
[214]Am J Transl Res. 2020 Feb 15;12(2):478-492.
[215]Am J Transl Res. 2019 Feb 15;11(2):806-818.
[216]Brain Res Bull. 2021 May 25;173:162-173.
[217]Vet Res. 2021 Oct 21;52(1):135.
[218]Toxicol Appl Pharmacol. 2021 Mar 11;115484.
[219]Toxicol Appl Pharmacol. 2019 Nov 1;382:114703.
[220]Toxicol Appl Pharmacol. 2019 Mar 1;366:83-95.
[221]Artif Cell Nanomed B. 2019 Dec;47(1):3087-3093.
[222]Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):685-695.
[223]Onco Targets Ther. 2021 Oct 22;14:5131-5144.
[224]J Dairy Sci. 2020 Dec;103(12):11636-11652.
[225]J Immunol Res. 2020 Feb 10;2020:6457879.
[226]Ann Transl Med. 2019 Dec;7(23):758.
[227]Toxics. 2022, 10(6), 285.
[228]Molecules. 2022, 27(5), 1577.
[229]Eur J Pharmacol. 2022 May 16;926:175034.
[230]Eur J Pharmacol. 2021 Jun 22;174270.
[231]Eur J Pharmacol. 2021, 173982.
[232]Endocrine. 2020 Apr;68(1):103-115.
[233]Nutr Metab. 2021 Nov 21;18(1):100.
[234]Infect Immun. 2020 Dec 14;IAI.00680-20.
[235]Dev Comp Immunol. 2021 Oct 14;104292.
[236]Chem Res Toxicol. 2022 Feb 11.
[237]Neural Regen Res. 2022.
[238]Food Sci Anim Resour. Oct 12, 2022.
[239]Environ Toxicol. 2022 Sep 29.
[240]Environ Toxicol. 2021 Feb;36(2):276-286.
[241]J Endod. 2018 May;44(5):751-758.
[242]J Neurol Sci. 2020 Mar 15;410:116679.
[243]Int J Mol Med. 2021 Jan;47(1):243-255.
[244]Bioorg Med Chem. 2020 Jul 1;28(13):115547
[245]Food Biosci. 7 May 2022, 101766.
[246]Food Biosci. 2021, 101268.
[247]Neuroscience. 2021 Jan 6;S0306-4522(20)30826-5.
[248]Phytochemistry. 2020 Dec;180:112531.
[249]Neurochem Res. 2020 Sep;45(9):2052-2064.
[250]Vet Microbiol. 2021, 109061.
[251]Eur Rev Med Pharmacol Sci. 2019 Aug;23(3 Suppl):1-8.
[252]Exp Eye Res. 2023 Jan 15.
[253]Biochem Bioph Res Co. 2020 Oct 15;531(2):187-194.
[254]Chin Med. 2021 Jul 19;16(1):58.
[255]Cytokine. 2021, 155502.
[256]Biosci Rep. 2020 May 29;40(5):BSR20193256.
[257]J Periodontal Res. 2021 Nov 13.
[258]Microb Pathog. 2021 Sep 30;105219.
[259]Microb Pathog. 2021 Aug 11;105136.
[260]J Microbiol. 2021 Jun 1.
[261]Peptides. 2019 Sep;119:170120.
[262]Diabetes Metab Syndr Obes. 2021 Nov 12;14:4523-4534.
[263]BMC Complement Altern Med. 2019 Aug 29;19(1):233.
[264]Parasit Vectors. 2021 Jul 8;14(1):358.
[265]Virology. 2017 Aug;508:150-158.
[266]BMC Pulm Med. 2018 Nov 27;18(1):178.
[267]Mol Cell Biochem. 2022 Jan 6.
[268]Fundam Clin Pharmacol. 2020 Oct;34(5):591-602.
[269]PLoS One. 2020 Sep 3;15(9):e0235824.
[270]Dis Markers. 2018 Apr 17;2018:7413027.
[271]Cell J. 2022 Dec 1;24(12):732-740.
[272]Biochem Cell Biol. 2017 Feb;95(1):64-68.
[273]Mycopathologia. 2021 Jun 4.
[274]Exp Physiol. 2020 Dec 17.
[275]AAPS PharmSciTech. 2022 Mar 14;23(3):83.
[276]Oncol Lett. 2020 Apr;19(4):3269-3277.
[277]Biomed Res Int. 2019 Jul 10;2019:5347804.
[278]Acupunct Med. 2021 Jul 24;9645284211020766.
[279]FEBS Open Bio. 2020 Mar;10(3):434-443.
[280]Bioengineered. 2022 Apr;13(4):8747-8758.
[281]Mol Med Rep. 2021 Oct;24(4):709.
[282]Mol Med Rep. 2020 Jul;22(1):566-574.
[283]Mol Med Rep. 2019 Nov;20(5):4576-4586.
[284]Anal Cell Pathol. 2022 Sep 27;2022:9358583.
[285]Chem Biodivers. 2019 Aug;16(8):e1900325.
[286]J Interferon Cytokine Res. 2021 Dec;41(12):439-449.
[287]J Interferon Cytokine Res. 2019 Apr;39(4):224-232.
[288]Chin J Nat Med. 2023 Jan;21(1):36-46.
[289]Chin J Nat Medicines. 2020 Oct;18(10):738-748.
[290]Med Sci Monit. 2020 Aug 7;26:e925298.
[291]Med Sci Monit. 2019 Jun 21;25:4609-4616.
[292]Drug Dev Res. 2022 Sep 1.
[293]Biol Pharm Bull. 2022 May 31.
[294]Eur Arch Otorhinolaryngol. 2019 Mar;276(3):767-774.
[295]Exp Ther Med. October 28, 2021.
[296]Exp Ther Med. October 12, 2021.
[297]Exp Ther Med. October 20, 2021.
[298]Exp Ther Med. 2021 Mar 8.
[299]Exp Ther Med. 2020 Mar;19(3):2243-2251.
[300]Exp Ther Med. 2020 Mar;19(3):1824-1834.
[301]J Clin Neurosci. 2020 Aug;78:365-370.
[302]Mol Cell Toxicol (2019) 15:209-219
[303]Reprod Domest Anim. 2021 May 12.
[304]Can Respir J. 10 Oct 2022.
[305]Pharmacology. 2021 Oct 29;1-14.
[306]J Cardiothorac Surg. 2021 May 10;16(1):127.
[307]Biomed Res. 2017; 28 (8): 3383-3386
[308]J Asian Nat Prod Res. 2020 Sep;22(9):850-863.
[309]Int J Clin Exp Med. 2017;10(9):13542-13549.
[310]Research Square Print. November 29th, 2022.
[311]Authorea. 2022.
[312]Research Square Print. November 15th, 2022
[313]Research Square Print. September 20th, 2022.
[314]Chinese Herbal Medicines. 1 September 2022.
[315]Research Square Print. 2022 Aug.
[316]Research Square Preprint. 2022 May.
[317]Food Chem X. 2022 Apr 30;14:100321.
[318]BMC Complement Med Ther. 2022 Apr 6;22(1):100.
[319]Stem Cell Rev Rep. 2022 Jan 26.
[320]Research Square Preprint. 2022 Jan.
[321]Food Chem X. 15 January 2022, 100211.
[322]Research Square Preprint. 2022 Feb.
[323]bioRxiv. January 18, 2022.
[324]Research Square Preprint. 2021 Dec.
[325]SSRN. 8 Nov 2021.
[326]Research Square Preprint. 2021 Oct.
[327]Research Square Preprint. 2021 Sep.
[328]Research Square Preprint. 2021 May.
[329]Research Square Preprint. 2021 Jan.
[330]Programa de Doctorado en Biomedicina. 2020 Sep.
[331]bioRxiv. 2020 Jun.
[332]Patent. US20180263995A1.
[333]Cell Physiol Biochem. 2018;46(5):1779-1792.
[334]Neuropsychiatry (London). 2018;8(4);1132-1139.
[335]Patent. US20170349880A1.
[336]Oncotarget. 2017 Oct 19;8(60):101965-101983.
[337]School of Healthcare Science. Manchester Metropolitan University. 2017 May.
[338]China Biotechnology. 2017, 37(12): 40-48.
[339]Chin Arch Otolaryngol Head Neck Surg. 2016,23(01):49-52.
[340]Harvard Medical School LINCS LIBRARY

Summary

Adezmapimod (SB 203580) is a selective and ATP-competitive p38 MAPK inhibitor with IC ₅₀ s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 , respectively. Adezmapimod inhibits LCK, GSK3β and PKBα with IC ₅₀ s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod does not disrupt JNK activity and is an autophagy and mitophagy activator ^[1] .

IC50 & Target

p38

50 nM (IC ₅₀ )

p38β2

500 nM (IC ₅₀ )

In Vitro

Adezmapimod (SB 203580) (preincubated with 0-30 μM for 1 h and cultured for 24 h in the presence of 20 ng/mL IL-2) prevents the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC ₅₀ of 3-5 μM ^[1] .
SB203580 blocks PKB phosphorylation (IC ₅₀ 3-5 μM). SB203580 inhibitsthe phosphorylation of Ser473 in a dose-dependent manner in both CT6 and activated human T cells and IL-2-responsive BA/F3 F7 B cells ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay ^[1]

Cell Line:	CT6, BA/F3 cell line F7, and PBMC/T cells
Concentration:	0-30 μM
Incubation Time:	Preincubated with 0-30 μM SB203580 for 1 h and cultured for 24 h in the presence of 20 ng/mL IL-2
Result:	Prevented the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC ₅₀ of 3-5 μM.

Western Blot Analysis ^[1]

Cell Line:	CT6 cells, activated human T cells, and BA/F3 F7 cells
Concentration:	0-30 μM
Incubation Time:	Preincubated with 0-30 μM SB203580 for 1 h before stimulating with 20 ng/mL IL-2 for 5 min
Result:	Inhibited the phosphorylation of PKB at Ser473 in a dose-dependent manner.

In Vivo

Adezmapimod (SB 203580) (5 mg/kg/day; intra peritoneal injected daily for 16 consecutive days, in female atymic Nu/Nu mice) treatment, p38WT tumors show a significantly smaller tumor burden when compared with p38TM tumors that were treated in parallel ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Six-week-old female atymic Nu/Nu mice CAL27 p38WT and p38TM tumors ^[1]
Dosage:	5 mg/kg/day
Administration:	Intra peritoneal injected daily for 16 consecutive days
Result:	After 2 weeks treatment, CAL27 p38WT tumors were significantly smaller; CAL27 p38TM tumors were not affected by the p38 inhibitor (n=10).

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 20 mg/mL ( 52.99 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6495 mL	13.2475 mL	26.4950 mL
5 mM	0.5299 mL	2.6495 mL	5.2990 mL
10 mM	0.2649 mL	1.3247 mL	2.6495 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 0.5% CMC-Na /saline water

Solubility: 16.67 mg/mL (44.17 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 5% DMSO >> 40% PEG300 >> 5% Tween-80 >> 50% saline

Solubility: ≥ 2.5 mg/mL (6.62 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 2 mg/mL (5.30 mM); Clear solution; Need ultrasonic
4.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2 mg/mL (5.30 mM); Clear solution; Need ultrasonic
5.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: 2 mg/mL (5.30 mM); Clear solution; Need ultrasonic

* All of the co-solvents are available by MCE.

References

[1] Davies SP, et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105.
[2] Lali FV, et al. The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitoge
[3] Leelahavanichkul K, et al. A role for p38 MAPK in head and neck cancer cell growth and tumor-induced angiogenesis and lymphangiogenesis. Mol Oncol. 2014 Feb;8(1):105-18.

Synonyms

Pyridine, 4-[4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]-

Pyridine, 4-[5-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-4-yl]-

4-[4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine

SB 203580

PB 203580

RWJ 64809

BIRB 203580

4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine

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