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[CAS NO. 153168-05-9] Pleconaril
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-19952 |
| Brand: | MCE |
| CAS: | 153168-05-9 |
Overview
| MDL | MFCD00923611 |
|---|---|
| Molecular Weight | 381.35 |
| Molecular Formula | C18H18F3N3O3 |
| SMILES | FC(C1=NC(C2=CC(C)=C(OCCCC3=CC(C)=NO3)C(C)=C2)=NO1)(F)F |
Summary
Pleconaril is a capsid inhibitor used previously to treat enterovirus infections. Pleconaril is effective in inhibiting replication with an IC50 of 50 nM. Target: enterovirus Pleconaril is a capsid inhibitor designed to dock within a hydrophobic pocket formed by the capsid proteins VP1, VP3 and VP2. Pleconaril leads to stiffening of the capsid structure, preventing RNA release into the cell. Pleconaril has been used as treatment on a compassionateuse basis in neonates and immunodeficient patients with severe EV infections.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT00394914 | Merck Sharp & Dohme LLC |
Asthma|Common Cold|Picornavirus Infection|Rhinovirus
|
August 2006 | Phase 2 |
| NCT00031512 | National Institute of Allergy and Infectious Diseases (NIAID) |
Enteroviral Sepsis
|
June 2001 | Phase 2 |
| NCT04838145 | Oslo University Hospital |
Type1 Diabetes Mellitus|Enterovirus
|
August 30, 2018 | Phase 2 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 262.23 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.6223 mL | 13.1113 mL | 26.2226 mL |
| 5 mM | 0.5245 mL | 2.6223 mL | 5.2445 mL |
| 10 mM | 0.2622 mL | 1.3111 mL | 2.6223 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (6.56 mM); Clear solution
References
- [1] Benschop KS, et al. Genetic and antigenic structural characterization for resistance of echovirus 11 to pleconaril in an immunocompromised patient. J Gen Virol. 2015 Mar;96(Pt 3):571-9.
- [2] Lacroix C, et al. http://www.ncbi.nlm. In vitro characterisation of a pleconaril/pirodavir-like compound with potent activity against rhinoviruses. Virol J. 2015 Jul 14;12:106.
Synonyms
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