[CAS NO. 153168-05-9] Pleconaril

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PRODUCTS SPECIFICATIONS [153168-05-9]

Catalog

HY-19952

Brand

MCE

CAS

153168-05-9

DESCRIPTION [153168-05-9]

Overview

MDL	MFCD00923611
Molecular Weight	381.35
Molecular Formula	C18H18F3N3O3
SMILES	FC(C1=NC(C2=CC(C)=C(OCCCC3=CC(C)=NO3)C(C)=C2)=NO1)(F)F

For research use only. We do not sell to patients.

Summary

Pleconaril is a capsid inhibitor used previously to treat enterovirus infections. Pleconaril is effective in inhibiting replication with an IC50 of 50 nM. Target: enterovirus Pleconaril is a capsid inhibitor designed to dock within a hydrophobic pocket formed by the capsid proteins VP1, VP3 and VP2. Pleconaril leads to stiffening of the capsid structure, preventing RNA release into the cell. Pleconaril has been used as treatment on a compassionateuse basis in neonates and immunodeficient patients with severe EV infections.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT00394914	Merck Sharp & Dohme LLC	Asthma\|Common Cold\|Picornavirus Infection\|Rhinovirus	August 2006	Phase 2
NCT00031512	National Institute of Allergy and Infectious Diseases (NIAID)	Enteroviral Sepsis	June 2001	Phase 2
NCT04838145	Oslo University Hospital	Type1 Diabetes Mellitus\|Enterovirus	August 30, 2018	Phase 2

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 262.23 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6223 mL	13.1113 mL	26.2226 mL
5 mM	0.5245 mL	2.6223 mL	5.2445 mL
10 mM	0.2622 mL	1.3111 mL	2.6223 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (6.56 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.56 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

1,2,4-Oxadiazole, 3-[3,5-dimethyl-4-[3-(3-methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoromethyl)-

3-[3,5-Dimethyl-4-[3-(3-methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole

Win 63843

VP 63843

Pleconaril

Picovir