MDL | MFCD04974488 |
---|---|
Molecular Weight | 794.47 |
Molecular Formula | C28H62Cl8N8 |
SMILES | [H]Cl.[H]Cl.[H]Cl.[H]Cl.[H]Cl.[H]Cl.[H]Cl.[H]Cl.N1(CCCNCCNCCCNCC1)CC2=CC=C(C=C2)CN3CCCNCCNCCCNCC3 |
Plerixafor octahydrochloride (AMD3100 octahydrochloride) is a selective CXCR4 antagonist with an IC 50 of 44 nM.
125 I-CXCL12-CXCR4 44 nM (IC 50 ) |
125 I-CXCL12-CXCR7
|
HIV-1 1-10 nM (EC 50 ) |
HIV-2 1-10 nM (EC 50 ) |
The CXCR4 inhibitor Plerixafor (AMD3100) is a potent inhibitor of CXCL12-mediated chemotaxis (IC 50 , 5.7 nM) with a potency slightly better than its affinity for CXCR4. Treating the cells with CCX771 or CXCL11 has no effect on CXCL12-mediated MOLT-4 or U937 TEM. In contrast, 10 μM Plerixafor inhibits CXCL12-mediated TEM in both cells lines [1] . Plerixafor (10 μM)-treated cells show a moderate reduction in cell proliferation compared to CXCL12-stimulated cells, which do not reach statistical significance [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Plerixafor (2 mg/kg) administration to UUO mice exacerbates renal interstitial T cell infiltration, resulting in increased production of the pro-inflammatory cytokines IL-6 and IFN-γ and decreased expression of the anti-inflammatory cytokine IL-10 [3] . Both perivascular and interstitial fibrosis are significantly reduced by the CXCR4 antagonist, Plerixafor (AMD3100) at 8 weeks [4] . LD50, mouse, SC: 16.3 mg/kg; LD50, rat, SC: >50 mg/kg; LD50, mouse and rat, IV injection: 5.2 mg/kg.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
NCT Number | Sponsor | Condition | Start Date | Phase |
---|---|---|---|---|
NCT02703779 | Siddhartha Ganguly|University of Kansas Medical Center |
Multiple Myeloma
|
March 2016 | Phase 2 |
NCT02056210 | University of Padova|Azienda Ospedaliera di Padova |
Diabetes
|
February 2014 | Phase 4 |
NCT00967785 | National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) |
Leukopenia|Neutropenia|Infections|Warts|Myelokathexis
|
January 6, 2010 | Phase 1|Phase 2 |
NCT01225419 | University Hospital, Clermont-Ferrand |
Children Cancer, Solid Tumor
|
September 2010 | Phase 2 |
NCT03653247 | Sangamo Therapeutics |
Sickle Cell Disease
|
March 6, 2019 | Phase 1|Phase 2 |
NCT01042717 | Shi, Patricia, M.D.|Genzyme, a Sanofi Company |
Multiple Myeloma|Non-Hodgkins Lymphoma
|
February 2010 | Not Applicable |
NCT03240861 | Jonsson Comprehensive Cancer Center|California Institute for Regenerative Medicine (CIRM) |
HLA-A*0201 Positive Cells Present|Locally Advanced Malignant Neoplasm|NY-ESO-1 Positive|Unresectable Malignant Neoplasm|Sarcoma
|
July 26, 2017 | Phase 1 |
NCT02790957 | Gian Paolo Fadini|University Hospital Padova|University of Padova |
Diabetes|Wounds|Critical Limb Ischemia
|
June 2016 | Phase 2 |
NCT01526096 | University of Chicago |
Myeloma
|
July 12, 2011 | Phase 1 |
NCT01977677 | Lawrence Recht|National Cancer Institute (NCI)|Stanford University |
Adult Ependymoblastoma|Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma|Adult Medulloblastoma|Adult Mixed Glioma|Adult Oligodendroglial Tumors|Adult Pineoblastoma|Adult Supratentorial Primitive Neuroectodermal Tumor (PNET)
|
November 2014 | Phase 1|Phase 2 |
NCT01353937 | NYU Langone Health|National Institutes of Health (NIH)|Genzyme, a Sanofi Company |
Diabetic Ulcer
|
April 2014 | Phase 1 |
NCT03157804 | Hospital Infantil Universitario Niño Jesús, Madrid, Spain|Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT)|Centro de Investigación en Red de Enfermedades Raras (CIBERER)|Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz|Hospital Vall d´Hebron|Universitat Autonoma de Barcelona |
Fanconi Anemia
|
January 7, 2016 | Phase 1|Phase 2 |
NCT01206075 | University of Washington|National Heart, Lung, and Blood Institute (NHLBI)|George Papanicolaou Hospital|Genzyme, a Sanofi Company |
Beta-Thalassemia
|
October 2010 | Not Applicable |
NCT02343666 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI)|National Heart, Lung, and Blood Institute (NHLBI) |
Human Immunodeficiency Virus 1 Positive|Stage I Adult Hodgkin Lymphoma|Stage I Adult Non-Hodgkin Lymphoma|Stage II Adult Hodgkin Lymphoma|Stage II Adult Non-Hodgkin Lymphoma|Stage III Adult Hodgkin Lymphoma|Stage III Adult Non-Hodgkin Lymphoma|Stage IV Adult Hodgkin Lymphoma|Stage IV Adult Non-Hodgkin Lymphoma
|
August 15, 2016 | Phase 1 |
NCT02678533 | Assistance Publique - Hôpitaux de Paris|EuroFancolen |
Fanconi Anemia
|
February 10, 2017 | Phase 1|Phase 2 |
NCT01288573 | Genzyme, a Sanofi Company|Sanofi |
Ewing´s Sarcoma+Soft Tissue Sarcoma|Neuroblastoma|Brain Tumors
|
March 3, 2014 | Phase 1|Phase 2 |
NCT00822770 | M.D. Anderson Cancer Center|Genzyme, a Sanofi Company |
Stem Cell Transplantation|Leukemia
|
January 2009 | Phase 1|Phase 2 |
NCT01339572 | University of Florida |
Non-Hodgkin´s Lymphoma|Multiple Myeloma
|
April 2011 | Phase 2 |
NCT02989701 | Alessandra Biffi|Boston Children´s Hospital |
Sickle Cell Disease Without Crisis
|
January 2017 | Phase 1 |
NCT02231879 | National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) |
Myelokathexis|Infections|Neutropenia|Warts|Hypogammaglobulinemia
|
October 14, 2014 | Phase 2|Phase 3 |
NCT01146834 | Weill Medical College of Cornell University|Millennium Pharmaceuticals, Inc. |
Multiple Myeloma
|
March 2011 | Phase 3 |
NCT00445302 | Genzyme, a Sanofi Company|Sanofi |
Renal Impairment
|
January 2006 | Phase 1 |
NCT00322127 | National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) |
Healthy Volunteers
|
June 14, 2006 | Phase 1 |
NCT01916577 | University of Colorado, Denver|Sanofi |
COPD|Cystic Fibrosis|Pulmonary Fibrosis
|
August 2013 | Phase 1 |
NCT00322491 | Genzyme, a Sanofi Company|AnorMED|Sanofi |
Lymphoma, Non-Hodgkin|Multiple Myeloma
|
March 2004 | Phase 2 |
NCT04045821 | Reproductive Medicine Associates of New Jersey |
Infertility of Uterine Origin
|
January 17, 2020 | Not Applicable |
NCT01319864 | Seattle Children´s Hospital|Children´s Healthcare of Atlanta|Pediatric Oncology Experimental Therapeutics Investigation Consortium |
Relapsed+Refractory AML|Relapsed+Refractory ALL|Secondary AML+MDS|Acute Leukemia of Ambiguous Lineage|AML|ALL
|
March 2011 | Phase 1 |
NCT00914849 | Washington University School of Medicine |
Hematologic Neoplasms
|
August 2009 | Phase 2 |
NCT02179970 | CCTU- Cancer Theme|Sanofi|Stand Up To Cancer|CRUK Cambridge Institute|Lustgarten Foundation|National Institute for Health Research, United Kingdom|Cambridge University Hospitals NHS Foundation Trust |
Pancreatic Adenocarcinoma Metastatic|Ovarian Serous Adenocarcinoma|Colorectal Cancer Metastatic
|
June 2015 | Phase 1 |
NCT01280955 | Mitchell Horwitz, MD|Genzyme, a Sanofi Company|Duke University |
Failure of Bone Marrow Graft
|
December 2011 | Phase 1|Phase 2 |
NCT01818284 | M.D. Anderson Cancer Center|Proteonomix, Inc. |
Blood And Marrow Transplantation
|
October 2013 | Phase 2 |
NCT01547806 | National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) |
Plasma Cell Myeloma|Multiple Myeloma
|
February 22, 2012 | Phase 2 |
NCT01097057 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI) |
Non-Hodgkin Lymphoma
|
November 9, 2010 | Phase 2 |
NCT02193191 | Memorial Sloan Kettering Cancer Center|Sanofi|New York Blood Center|Weill Medical College of Cornell University|Duke University |
Sickle Cell Disease
|
September 2014 | Phase 1 |
NCT01186224 | University of Liverpool|Genzyme, a Sanofi Company |
Multiple Myeloma|Plasma Cell Dyscrasia|Lymphoma|Lymphoproliferative Disorders
|
May 2010 | Not Applicable |
NCT02682953 | University of Maryland, Baltimore|Healogics |
Bone Marrow Transplantation|Hematopoietic Stem Cells|Multiple Myeloma|Lymphoma
|
October 2015 | Phase 2 |
NCT03277209 | Weill Medical College of Cornell University|Cambridge University Hospitals NHS Foundation Trust |
Pancreas Cancer
|
July 25, 2017 | Phase 1 |
NCT00669669 | Fred Hutchinson Cancer Center |
Glioblastoma|Gliosarcoma
|
February 25, 2009 | Phase 1|Phase 2 |
NCT01301963 | Case Comprehensive Cancer Center|National Cancer Institute (NCI) |
Refractory Multiple Myeloma
|
July 2011 | Phase 3 |
NCT02212535 | Assistance Publique - Hôpitaux de Paris |
Major Sickle Cell Syndrome of Type SS or Sβ Thalassemia
|
January 15, 2016 | Phase 1|Phase 2 |
NCT02931071 | Hospital Universitari Vall d´Hebron Research Institute|CIEMAT|CIBERER |
Fanconi Anemia
|
September 2013 | Phase 2 |
NCT02006225 | Tel-Aviv Sourasky Medical Center|Sanofi |
Autologous Stem Cell Transplantation
|
February 2014 | Phase 4 |
NCT01753453 | Sanofi|Genzyme, a Sanofi Company |
Multiple Myeloma
|
June 2013 | Phase 2 |
NCT00998049 | Mayo Clinic |
Multiple Myeloma|Refractory Multiple Myeloma|Stage I Multiple Myeloma|Stage II Multiple Myeloma|Stage III Multiple Myeloma
|
December 2009 | Phase 2 |
NCT01331018 | Fred Hutchinson Cancer Center|National Heart, Lung, and Blood Institute (NHLBI)|Rocket Pharma Limited |
Fanconi Anemia
|
February 22, 2012 | Phase 1 |
NCT00943943 | M.D. Anderson Cancer Center|Bayer|Genzyme, a Sanofi Company|Amgen|National Cancer Institute (NCI)|Georgia Institute of Technology |
Acute Myelogenous Leukemia|Leukemia
|
October 29, 2010 | Phase 1 |
NCT04058145 | Massachusetts General Hospital|Merck Sharp & Dohme LLC|AperiSys, Inc |
Head and Neck Cancer
|
September 30, 2019 | Phase 2 |
NCT00322842 | Genzyme, a Sanofi Company|AnorMED|Sanofi |
Lymphoma, Non-Hodgkin|Multiple Myeloma
|
September 2004 | Phase 2 |
NCT01160354 | M.D. Anderson Cancer Center|Genzyme, a Sanofi Company |
Acute Myelogenous Leukemia
|
August 2010 | Phase 1|Phase 2 |
NCT03547830 | Federal Research Institute of Pediatric Hematology, Oncology and Immunology |
Chronic Granulomatous Disease
|
April 13, 2019 | Phase 2 |
NCT00322387 | Genzyme, a Sanofi Company|Sanofi |
Lymphoma, Non-Hodgkin|Multiple Myeloma
|
April 2004 | Phase 2 |
NCT02221492 | Genzyme, a Sanofi Company|Sanofi |
Lymphoma
|
November 2014 | Phase 2 |
NCT05343572 | Hugh Taylor|Yale University |
Asherman Syndrome|Atrophic Endometrium|Recurrent Implantation Failure
|
September 2022 | Early Phase 1 |
NCT01373229 | David Rizzieri, MD|Celgene Corporation|Genzyme, a Sanofi Company|Duke University |
Leukemia, Lymphocytic, Chronic, B-Cell
|
January 2012 | Phase 1 |
NCT05007652 | Kyowa Kirin Co., Ltd. |
Multiple Myeloma and Malignant Lymphoma
|
August 10, 2021 | Phase 2 |
NCT01579149 | Genzyme, a Sanofi Company|Sanofi |
Healthy Volunteer
|
September 2011 | Phase 1 |
NCT01026987 | Washington University School of Medicine |
Stem Cell Transplant Patients
|
April 29, 2010 | Phase 1 |
NCT01164345 | Sheba Medical Center |
Non-Hodgkin´s Lymphoma|Hodgkin´s Lymphoma|Stem Cell Mobilization|Autologous Stem Cell Transplantation
|
June 2010 | Phase 2 |
NCT04817345 | St. Jude Children´s Research Hospital|Doris Duke Charitable Foundation |
Sickle Cell Disease
|
November 2022 | Phase 2 |
NCT01954914 | Technische Universität Dresden|University Hospital Carl Gustav Carus|Cellex Gesellschaft für Zellgewinnung mbH Dresden|Cellex Gesellschaft für Zellgewinnung mbH Köln |
Blood Stem Cell Harvest Failure
|
December 2013 | Phase 2 |
NCT01068301 | St. Jude Children´s Research Hospital|Genzyme, a Sanofi Company |
Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Chronic Myeloid Leukemia|Myelodysplastic Syndrome|Non-Hodgkin´s Lymphoma
|
May 2010 | Phase 1 |
NCT00082329 | National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) |
Healthy
|
June 18, 2004 | Phase 2 |
NCT05087212 | Sanofi |
Autologous Haematopoietic Stem Cell Transplant
|
October 22, 2021 | Phase 4 |
NCT01076270 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI) |
Accelerated Phase Chronic Myelogenous Leukemia|Adult Acute Lymphoblastic Leukemia in Remission|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Atypical Chronic Myeloid Leukemia, BCR-ABL Negative|Blastic Phase Chronic Myelogenous Leukemia|Chronic Phase Chronic Myelogenous Leukemia|de Novo Myelodysplastic Syndromes|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Myelodysplastic+Myeloproliferative Neoplasm, Unclassifiable|Nodal Marginal Zone B-cell Lymphoma|Noncontiguous Stage II Adult Burkitt Lymphoma|Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma|Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma|Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma|Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma|Noncontiguous Stage II Adult Lymphoblastic Lymphoma|Noncontiguous Stage II Grade 1 Follicular Lymphoma|Noncontiguous Stage II Grade 2 Follicular Lymphoma|Noncontiguous Stage II Grade 3 Follicular Lymphoma|Noncontiguous Stage II Mantle Cell Lymphoma|Noncontiguous Stage II Marginal Zone Lymphoma|Noncontiguous Stage II Small Lymphocytic Lymphoma|Previously Treated Myelodysplastic Syndromes|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides+Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Hairy Cell Leukemia|Refractory Multiple Myeloma|Relapsing Chronic Myelogenous Leukemia|Secondary Acute Myeloid Leukemia|Secondary Myelodysplastic Syndromes|Splenic Marginal Zone Lymphoma|Stage I Multiple Myeloma|Stage II Multiple Myeloma|Stage III Adult Burkitt Lymphoma|Stage III Adult Diffuse Large Cell Lymphoma|Stage III Adult Diffuse Mixed Cell Lymphoma|Stage III Adult Diffuse Small Cleaved Cell Lymphoma|Stage III Adult Hodgkin Lymphoma|Stage III Adult Immunoblastic Large Cell Lymphoma|Stage III Adult Lymphoblastic Lymphoma|Stage III Chronic Lymphocytic Leukemia|Stage III Grade 1 Follicular Lymphoma|Stage III Grade 2 Follicular Lymphoma|Stage III Grade 3 Follicular Lymphoma|Stage III Mantle Cell Lymphoma|Stage III Marginal Zone Lymphoma|Stage III Multiple Myeloma|Stage III Small Lymphocytic Lymphoma|Stage IV Adult Burkitt Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Mixed Cell Lymphoma|Stage IV Adult Diffuse Small Cleaved Cell Lymphoma|Stage IV Adult Hodgkin Lymphoma|Stage IV Adult Immunoblastic Large Cell Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Stage IV Chronic Lymphocytic Leukemia|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma|Stage IV Marginal Zone Lymphoma|Stage IV Small Lymphocytic Lymphoma
|
June 2010 | Not Applicable |
NCT03055247 | IRCCS San Raffaele|Fondazione Telethon |
Chronic Granulomatous Disease X-linked (X-CGD)
|
November 6, 2015 | Phase 2 |
NCT01621477 | St. Jude Children´s Research Hospital|Assisi Foundation |
Acute Lymphoblastic Leukemia|Acute Myelocytic Leukemia|Chronic Myelocytic Leukemia|Juvenile Myelomonocytic Leukemia|Myelodysplastic Syndrome|Hodgkin or Non-Hodgkin Lymphoma|Sarcoma, Myeloid
|
August 2012 | Phase 2 |
NCT05088356 | Stanford University|Orca Biosystems, Inc. |
Allogeneic Hematopoietic Cell Transplantation (HCT)|Advanced Hematologic Malignancies|Acute Leukemia|Chronic Myelogenous Leukemia|Myelodysplastic Syndromes|Myeloproliferative Disorders
|
September 7, 2021 | Phase 1 |
NCT04177810 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|Genzyme, a Sanofi Company|American Association for Cancer Research|National Cancer Institute (NCI) |
Metastatic Pancreatic Cancer
|
November 16, 2020 | Phase 2 |
NCT00444912 | Genzyme, a Sanofi Company|Sanofi |
Non-Hodgkin Lymphoma|Hodgkin Disease
|
February 2006 | Phase 2 |
NCT01408043 | Case Comprehensive Cancer Center|National Cancer Institute (NCI) |
Adult Acute Lymphoblastic Leukemia in Remission|Adult Grade III Lymphomatoid Granulomatosis|Adult Nasal Type Extranodal NK+T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Cutaneous B-cell Non-Hodgkin Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Hepatosplenic T-cell Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Noncutaneous Extranodal Lymphoma|Peripheral T-cell Lymphoma|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia+Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides+Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Hairy Cell Leukemia|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|T-cell Large Granular Lymphocyte Leukemia|Testicular Lymphoma|Waldenström Macroglobulinemia
|
October 2011 | Not Applicable |
NCT00241358 | Washington University School of Medicine |
Leukemia, Myeloid, Acute|Leukemia, Myelogenous, Chronic|Leukemia, Lymphoblastic, Acute|Lymphocytic Leukemia, Chronic|Myelodysplastic Syndromes|Multiple Myeloma|Lymphoma, Non-Hodgkin|Hodgkin Disease
|
May 2004 | Phase 1|Phase 2 |
NCT01352650 | Weill Medical College of Cornell University|Genzyme, a Sanofi Company |
Acute Myeloid Leukemia
|
June 17, 2011 | Phase 1 |
NCT01767714 | Sanofi |
Non-Hodgkin´s Lymphoma
|
April 2013 | Phase 3 |
NCT00741780 | Genzyme, a Sanofi Company|Sanofi |
Multiple Myeloma|Autologous Transplantation
|
June 2006 | |
NCT03406091 | Fondazione EMN Italy Onlus |
Multiple Myeloma
|
November 26, 2015 | |
NCT04762875 | Magenta Therapeutics, Inc.|National Marrow Donor Program |
Related Donors Donating PBSC to a Family Member|Healthy Donors|Acute Myelogenous Leukemia|Acute Lymphoblastic Leukemia|Myelodysplastic Syndrome
|
June 16, 2021 | Phase 2 |
NCT01220375 | University Hospital Inselspital, Berne |
Myeloma
|
April 2010 | Phase 2 |
NCT01655875 | Emory University |
Pediatric Acute Myeloblastic Leukemia, Relapsed|Pediatric Acute Lymphoblastic Leukemia, Relapsed
|
June 2012 | Phase 1 |
NCT00720603 | Genzyme, a Sanofi Company|Sanofi |
Non-Hodgkin´s Lymphoma|Hodgkin´s Disease|Multiple Myeloma
|
||
NCT01141543 | University Health Network, Toronto|Princess Margaret Hospital, Canada |
Acute Myeloid Leukemia
|
May 2010 | |
NCT05470491 | National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) |
HIV|Hematologic Malignancies
|
November 27, 2022 | Phase 1|Phase 2 |
NCT00395967 | Genzyme, a Sanofi Company|Sanofi |
Multiple Myeloma|Lymphoma, Non-Hodgkin´s
|
April 2005 | Phase 2 |
NCT00396383 | Genzyme, a Sanofi Company|AnorMED|Sanofi |
Multiple Myeloma
|
November 2004 | Phase 2 |
NCT01149863 | Emory University|Genzyme, a Sanofi Company |
Autologous Transplantation
|
June 2010 | Phase 2 |
NCT03244930 | Hospital Universitario Dr. Jose E. Gonzalez |
Lymphoma, Non-Hodgkin|Lymphoma, Hodgkin|Myeloma|Stem Cell Transplant Complications
|
May 10, 2017 | Phase 2 |
NCT03182426 | University of Alberta|Alberta Innovates Health Solutions |
Diabetes Mellitus, Type 1
|
August 15, 2017 | Phase 1|Phase 2 |
NCT00075335 | National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) |
Healthy
|
January 2004 | Phase 2 |
NCT02200380 | Celldex Therapeutics |
For Donors|Related Donors Giving Peripheral Blood Stem Cells (PBSC) to a Sibling|For Recipients|Acute Myelogenous Leukemia (AML)|Acute Lymphoblastic Leukemia (ALL)|Myelodysplastic Syndrome (MDS)|Chronic Myelogenous Leukemia (CML)|Non-Hodgkins Lymphoma (NHL)|Hodgkins Disease (HD)|Chronic Lymphocytic Leukemia (CLL)
|
July 2014 | Phase 2 |
NCT01696461 | Center for International Blood and Marrow Transplant Research|Genzyme, a Sanofi Company|Sanofi |
Related Donors Donating PBSC to a Family Member|Acute Myelogenous Leukemia|Acute Lymphoblastic Leukemia|Myelodysplastic Syndrome|Chronic Myelogenous Leukemia|Non-Hodgkin´s Lymphoma|Hodgkin´s Disease|Chronic Lymphocytic Leukemia
|
May 2013 | Phase 2 |
NCT00396968 | Genzyme, a Sanofi Company|AnorMED|Sanofi |
Acute Myelogenous Leukemia|Myelodysplastic Syndromes
|
Phase 1|Phase 2 | |
NCT02221479 | Genzyme, a Sanofi Company|Sanofi |
Multiple Myeloma
|
October 2014 | Phase 2 |
NCT03612466 | Albert Einstein College of Medicine|National Cancer Institute (NCI) |
Osteosarcoma|Bone Metastases
|
August 2022 | Phase 1 |
NCT01027923 | Washington University School of Medicine |
Leukemia, Myeloid, Acute
|
May 2010 | Phase 1 |
NCT00838357 | Genzyme, a Sanofi Company|Sanofi |
Lymphoma (Non-Hodgkin´s Lymphoma)|Hodgkin´s Disease or Multiple Myeloma|Front Line Mobilization|Transplantation
|
September 2008 | Phase 3 |
NCT00396331 | Genzyme, a Sanofi Company|Sanofi |
Autologous Stem Cell Transplantation
|
October 2005 | Phase 2 |
NCT01413100 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI) |
Systemic Scleroderma
|
September 15, 2011 | Phase 2 |
NCT01318317 | City of Hope Medical Center|National Cancer Institute (NCI) |
Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Non-Hodgkin Lymphoma
|
September 19, 2011 | Phase 1|Phase 2 |
NCT00990054 | Genzyme, a Sanofi Company|Sanofi |
Acute Myeloid Leukemia
|
December 2009 | Phase 1 |
NCT00291811 | Genzyme, a Sanofi Company|Sanofi |
Autologous Stem Cell Transplant
|
October 2003 | |
NCT01236144 | Cardiff University|Leukaemia & Lymphoma Research Group|Experimental Cancer Medicine Centres |
Acute Myeloid Leukaemia|High Risk Myelodysplastic Syndrome
|
April 2011 | Phase 1|Phase 2 |
NCT03019809 | Federal Research Institute of Pediatric Hematology, Oncology and Immunology |
Wiskott-Aldrich Syndrome|Hematopoietic Stem Cell Transplantation|Graft Failure
|
June 2016 | Phase 2 |
NCT00694590 | Genzyme, a Sanofi Company|Sanofi |
Chronic Lymphocytic Leukemia (CLL)|Small Lymphocytic Lymphoma (SLL)
|
June 2008 | Phase 1 |
NCT01339039 | Patrick Y. Wen, MD|Dana-Farber Cancer Institute|Brigham and Women´s Hospital|Massachusetts General Hospital|Genzyme, a Sanofi Company |
High Grade Glioma: Glioblastoma (GBM)|High Grade Glioma: Gliosarcoma|Anaplastic Astrocytoma (AA)|Anaplastic Oligodendroglioma (AO)|Mixed Anaplastic Oligoastrocytoma (AOA)
|
December 2011 | Phase 1 |
NCT00903968 | Dana-Farber Cancer Institute|Brigham and Women´s Hospital|Genzyme, a Sanofi Company|Millennium Pharmaceuticals, Inc. |
Multiple Myeloma
|
June 1, 2009 | Phase 1|Phase 2 |
NCT01164475 | Genzyme, a Sanofi Company|Sanofi |
Non-Hodgkin´s Lymphoma
|
October 2010 | Phase 4 |
NCT01435343 | PETHEMA Foundation |
Acute Myeloblastic Leukemia
|
July 2012 | Phase 1|Phase 2 |
NCT02522572 | E. Steve Woodle|Sanofi-Synthelabo|University of Cincinnati |
Transplants and Implants
|
August 2015 | Phase 1|Phase 2 |
NCT05411575 | 4Living Biotech|4P-Pharma |
COVID-19 Acute Respiratory Distress Syndrome|COVID-19
|
July 19, 2022 | Phase 2 |
NCT03226691 | National Heart, Lung, and Blood Institute (NHLBI)|St. Jude Children´s Research Hospital|National Institutes of Health Clinical Center (CC) |
Sickle Cell Disease
|
July 25, 2017 | Phase 1 |
NCT00479115 | Children´s Hospital Medical Center, Cincinnati|National Heart, Lung, and Blood Institute (NHLBI) |
Fanconi Anemia
|
May 2007 | Phase 1|Phase 2 |
NCT03506802 | Jonsson Comprehensive Cancer Center|Novartis Pharmaceuticals |
HLA-A*0201 Positive Cells Present|NY-ESO-1 Positive Tumor Cells Present|Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma
|
July 10, 2018 | Phase 1 |
NCT00901225 | Duke University|Genzyme, a Sanofi Company |
Multiple Myeloma|Non-Hodgkins Lymphoma|Hodgkins Disease
|
May 2009 | Phase 2 |
NCT03664830 | City of Hope Medical Center |
Sickle Cell Disease
|
September 19, 2018 | Phase 1 |
NCT05445128 | Magenta Therapeutics, Inc.|bluebird bio |
Sickle Cell Disease
|
June 24, 2022 | Phase 2 |
NCT03746080 | Lawrence D Recht|Sanofi|Stanford University |
Glioblastoma|Glioblastoma With Primitive Neuronal Component|Gliosarcoma|Malignant Glioma|Oligodendroglial Component Present
|
December 4, 2018 | Phase 2 |
NCT02015013 | National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) |
Idiopathic CD4-Positive|T-Lymphocytopenia
|
January 15, 2014 | Phase 2 |
NCT01455025 | French Innovative Leukemia Organisation|Acute Leukemia French Association|Genzyme, a Sanofi Company |
Acute Myeloid Leukemia
|
January 2012 | Phase 1 |
NCT01158118 | Washington University School of Medicine |
Leukemia, Myeloid, Acute|Myelodysplastic Syndromes|Lymphoma, Non-Hodgkin|Hodgkin Disease|Leukemia, Lymphocytic, Chronic, B-Cell|Multiple Myeloma
|
April 1, 2011 | Phase 2 |
NCT00512252 | Washington University School of Medicine |
Leukemia, Myeloid, Acute
|
July 2007 | Phase 1|Phase 2 |
NCT01403896 | Stephen Couban|Genzyme, a Sanofi Company|Nova Scotia Health Authority |
Malignant Lymphoma, Stem Cell Type
|
April 2012 | Phase 2 |
NCT01711073 | Proteonomix, Inc.|University of Medicine and Dentistry of New Jersey|Numoda |
End Stage Liver DIsease
|
October 2012 | Phase 1 |
NCT01074060 | City of Hope Medical Center |
Refractory Multiple Myeloma|Stage I Multiple Myeloma|Stage II Multiple Myeloma|Stage III Multiple Myeloma
|
April 2010 | Phase 1 |
NCT00665314 | Genzyme, a Sanofi Company|Sanofi |
Lymphoma|Non Hodgkin´s Lymphoma|Hodgkin´s Disease|Multiple Myeloma
|
November 2007 | Phase 2 |
NCT00741325 | Genzyme, a Sanofi Company|Sanofi |
Non-Hodgkin´s Lymphoma|Autologous Transplantation
|
June 2006 | |
NCT00733824 | Washington University School of Medicine |
Lymphoma, Non-Hodgkin|Hodgkin Disease
|
November 2008 | Phase 1|Phase 2 |
NCT01738373 | Genzyme, a Sanofi Company|Sanofi |
Bone Marrow + Autologous Transplants
|
December 2011 | |
NCT02570542 | Memorial Sloan Kettering Cancer Center|Columbia University|NorthShore University HealthSystem|University of Rochester|Medical College of Wisconsin|University of Nebraska|Sanofi|University Hospitals Seidman Cancer Center |
Diffuse Large B-cell Lymphoma (DLBCL)|Relapsed Diffuse Large B-cell Lymphoma (DLBCL)|Refractory Diffuse Large B-cell Lymphoma (DLBCL)
|
October 2015 | Phase 2 |
NCT00906945 | Washington University School of Medicine |
Leukemia, Myeloid, Acute
|
February 2011 | Phase 1|Phase 2 |
NCT04552743 | Surbhi Sidana, MD|Stanford University |
Multiple Myeloma
|
October 5, 2020 | Phase 2 |
NCT02098109 | Washington University School of Medicine |
Multiple Myeloma|Lymphoma, Non-Hodgkin
|
August 20, 2014 | Phase 2 |
NCT00396266 | Genzyme, a Sanofi Company|Sanofi |
Multiple Myeloma|Lymphoma, Non-Hodgkin
|
January 2005 | Phase 2 |
NCT01610999 | Tufts Medical Center |
Chronic Lymphocytic Leukemia|Lymphoma|Multiple Myeloma
|
July 2013 | Phase 1 |
NCT01095757 | Emory University|Genzyme, a Sanofi Company |
Myeloma|Lymphoma
|
March 2010 | Phase 2 |
NCT03932864 | Magenta Therapeutics, Inc. |
Healthy Volunteers
|
April 22, 2019 | Phase 1 |
NCT05357482 | National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) |
Sickle Cell Anemia|Beta Thalassemia
|
May 12, 2022 | Phase 1|Phase 2 |
NCT01700608 | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano |
Lymphoma|Myeloma
|
September 2008 | |
NCT01037517 | CancerCare Manitoba |
Multiple Myeloma|Lymphoma
|
January 2010 | Phase 2 |
NCT01058993 | University of Washington |
Neutropenia
|
October 2010 | Phase 1 |
NCT01746173 | Dana-Farber Cancer Institute|Massachusetts General Hospital|Beth Israel Deaconess Medical Center |
T-cell Non-Hodgkin Lymphoma
|
July 2013 | Phase 2 |
NCT00103610 | Genzyme, a Sanofi Company|Sanofi |
Lymphoma, Non-Hodgkin
|
January 2005 | Phase 3 |
NCT01802892 | GlaxoSmithKline |
Transplantation, Stem Cell
|
November 2, 2012 | Phase 1 |
NCT00103662 | Genzyme, a Sanofi Company|Sanofi |
Multiple Myeloma
|
January 2005 | Phase 3 |
NCT01065129 | Washington University School of Medicine |
Myelodysplastic Syndromes
|
September 2, 2010 | Phase 1 |
NCT00396201 | Genzyme, a Sanofi Company|Sanofi |
Hodgkin´s Disease
|
November 2004 | Phase 2 |
Solid
Room temperature in continental US; may vary elsewhere.
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
H 2 O : 100 mg/mL ( 125.87 mM ; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
---|
1 mM | 1.2587 mL | 6.2935 mL | 12.5870 mL |
5 mM | 0.2517 mL | 1.2587 mL | 2.5174 mL |
10 mM | 0.1259 mL | 0.6294 mL | 1.2587 mL |
Add each solvent one by one: PBS
Solubility: 120 mg/mL (151.04 mM); Clear solution; Need ultrasonic