[CAS NO. 1557240-80-8] BNC375

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PRODUCTS SPECIFICATIONS [1557240-80-8]

Catalog

HY-128575

Brand

MCE

CAS

1557240-80-8

DESCRIPTION [1557240-80-8]

Overview

MDL	-
Molecular Weight	394.92
Molecular Formula	C19H23ClN2O3S
SMILES	ClC1=CC=C(OC)C(NC[C@H]2C(C)(C)[C@@H]2C3=CC=C(S(N)(=O)=O)C=C3)=C1

For research use only. We do not sell to patients.

Summary

BNC375 is a potent, selective, and orally available type I positive allosteric modulator of α7 nAChR s with an EC ₅₀ of 1.9 μM. BNC375 exhibits good CNS-drug like properties and clinical candidate potential. ^[1] .

In Vitro

BNC375 significantly potentiates the acetylcholine signal without changing the rapid receptor desensitization ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BNC375 (0.003-10.0 mg/kg, administered orally) exhibits the MED of 0.03 mg/kg, and achieves full reversal of the Scopolamine-induced impairment at 1.0 mg/kg in mouse T-maze model. BNC375 exhibits the plasm half-life (t _1/2 ) of 1.2 h ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 83.33 mg/mL ( 211.00 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5322 mL	12.6608 mL	25.3216 mL
5 mM	0.5064 mL	2.5322 mL	5.0643 mL
10 mM	0.2532 mL	1.2661 mL	2.5322 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (5.27 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (5.27 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (5.27 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Andrew J Harvey, et al. Discovery of BNC375, a Potent, Selective, and Orally Available Type I Positive Allosteric Modulator of α7 nAChRs. ACS Med Chem Lett. 2019 Mar 25;10(5):754-760.