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[CAS NO. 1558598-41-6] PFM01
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-116770 |
| Brand: | MCE |
| CAS: | 1558598-41-6 |
Overview
| MDL | MFCD02220972 |
|---|---|
| Molecular Weight | 293.40 |
| Molecular Formula | C14H15NO2S2 |
| SMILES | O=C1N(CC(C)C)C(S/C1=C\C2=CC=C(O)C=C2)=S |
Summary
IC50 & Target
Endonuclease [1]
In Vitro
PFM01 (100 μM) rescues the repair defect in 48BR (WT) and HSC62 (BRCA2-defective) primary cells
[1]
.
PFM01 (100 μM) diminishes the RAD51 foci formation in 1BR3 (WT) and HSC62 (BRCA2-defective) cells
[1]
.
PFM01 (100 μM) enhances non-homologous end-joining (NHEJ) in H1299 dA3 cells and reduces homologous recombination (HR) in U2OS DR-GFP cells
[1]
.
PFM01 substantially relieves the double-strand break (DSB) repair defect confers by mirin or PFM39 in irradiated G2 cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 340.83 mM )
Ethanol : 25 mg/mL ( 85.21 mM ; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.4083 mL | 17.0416 mL | 34.0832 mL |
| 5 mM | 0.6817 mL | 3.4083 mL | 6.8166 mL |
| 10 mM | 0.3408 mL | 1.7042 mL | 3.4083 mL |
References
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