[CAS NO. 1576-37-0] BTS

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PRODUCTS SPECIFICATIONS [1576-37-0]

Catalog

HY-16690

Brand

MCE

CAS

1576-37-0

DESCRIPTION [1576-37-0]

Overview

MDL	MFCD00159328
Molecular Weight	261.34
Molecular Formula	C14H15NO2S
SMILES	O=S(NCC1=CC=CC=C1)(C2=CC=C(C)C=C2)=O

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Nat Commun. 2018 Nov 19;9(1):4848.

Summary

BTS (N-Benzyl-p-toluenesulfonamide) is a potent and selective inhibitor of skeletal muscle myosin II subfragment 1 (S1) ATPase activity, with an IC ₅₀ s of ~5 µM for actin- and Ca ²⁺ -stimulated myosin S1 ATPase. BTS specifically inhibits the contraction of fast skeletal muscle fibers ^[1] ^[2] .

IC50 & Target

IC50: ~5 µM (skeletal muscle myosin II S1 ATPase)

In Vitro

BTS (2-12 μM) inhibits the Ca ²⁺ -stimulated ATPase activity of myosin S1 in the absence of actin, with an IC ₅₀ of ~5 µM ^[1] .
BTS (2-20 μM) reversibly inhibits the gliding motility rate of heavy meromyosin (HMM) ^[1] .
BTS (100 μM) releases myosin from actin in the presence of ADP ^[1] .
BTS (0-20 μM) reversibly inhibits isometric Ca ²⁺ -activated tension in skinned skeletal muscle fibres from rabbit and frog, with IC ₅₀ s of ~3 µM and 1 µM, respectively ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 33.33 mg/mL ( 127.54 mM )

H ₂ O : 0.1 mg/mL ( 0.38 mM ; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8264 mL	19.1322 mL	38.2643 mL
5 mM	0.7653 mL	3.8264 mL	7.6529 mL
10 mM	0.3826 mL	1.9132 mL	3.8264 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (9.57 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (9.57 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (9.57 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Benzenesulfonamide, 4-methyl-N-(phenylmethyl)-

p-Toluenesulfonamide, N-benzyl-

4-Methyl-N-(phenylmethyl)benzenesulfonamide

N-Benzyl-p-toluenesulfonamide

N-Tosylbenzylamine

N-Benzyl-p-tosylamide

N-Benzyl-4-methylbenzenesulfonamide

NSC 37123

Benzyl(4-toluenesulfonyl)amine