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[CAS NO. 15826-37-6] Cromolynsodium
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-B0320A |
| Brand: | MCE |
| CAS: | 15826-37-6 |
Overview
| MDL | MFCD22575281 |
|---|---|
| Molecular Weight | 512.33 |
| Molecular Formula | C23H14Na2O11 |
| SMILES | OC(COC1=C2C(C=C(C(O[Na])=O)OC2=CC=C1)=O)COC3=C4C(C=C(C(O[Na])=O)OC4=CC=C3)=O |
3 Publications Citing Use of MCE
Summary
Cromolyn sodium (Disodium Cromoglycate; FPL-670) is an antiallergic drug. Cromolyn sodium is a GSK-3β inhibitor with an IC 50 of 2.0 µM.
IC50 & Target
|
GSK-3β 2 μM (IC 50 ) |
In Vitro
Cromolyn sodium (Disodium Cromoglycate; FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Pretreatment of IIR mice with Cromolyn sodium (Disodium Cromoglycate; FPL-670) prior to ischemia exhibited no changes of ET-1 levels, injury score and inflammation (P>0.05, PreCr vs. M groups). In conclusion, administration of Cromolyn (sodium) after reperfusion, but not prior to ischemia, attenuates IIRI by downregulating ET-1 and suppressing sustained MC activation [1] . Cromolyn (sodium) has a role in the prevention of Chronic lung disease(CLD). Cromolyn (sodium) cannot be recommended for the prevention of CLD in preterm infants [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT04428775 | AZTherapies, Inc. |
Amyotrophic Lateral Sclerosis
|
September 8, 2020 | Phase 2 |
| NCT04846348 | Joseph Butterfield|Mayo Clinic |
Cutaneous Mastocytoses
|
July 26, 2021 | Phase 2 |
| NCT03167216 | Northwestern University|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
Chronic Prostatitis With Chronic Pelvic Pain Syndrome
|
August 1, 2017 | Early Phase 1 |
| NCT04570644 | AZTherapies, Inc. |
Healthy Volunteers|Alzheimer Disease
|
August 28, 2020 | Phase 1 |
| NCT01933464 | University of California, San Diego |
Papulopustular Rosacea
|
August 2013 | Phase 1|Phase 2 |
| NCT02371941 | University of Tennessee |
Eosinophilic Esophagitis
|
December 2014 | Phase 4 |
| NCT05077917 | Texas Tech University Health Sciences Center, El Paso |
COVID-19 Pneumonia|COVID-19 Respiratory Infection|Pneumonia, Viral
|
November 15, 2021 | Phase 3 |
| NCT02566252 | Pulmotect, Inc.|WCCT Global |
Healthy
|
July 2015 | Phase 1 |
| NCT03202147 | AZTherapies, Inc. |
Ischemic Stroke|Post-stroke Cognitive Impairment
|
December 2023 | Phase 2 |
| NCT01175525 | Wolfson Medical Center |
Acute Stroke
|
Phase 3 | |
| NCT00745199 | Shiraz University of Medical Sciences |
End Stage Renal Disease|Pruritus
|
May 2008 | Phase 2 |
| NCT01841307 | University of California, San Francisco|Aradign Corportation|National Heart, Lung, and Blood Institute (NHLBI) |
Gastroesophageal Reflux|Respiratory Aspiration|Idiopathic Pulmonary Fibrosis|Lung Transplantation
|
July 2015 | Phase 1 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
H 2 O : 50 mg/mL ( 97.59 mM ; Need ultrasonic)
DMSO : 25 mg/mL ( 48.80 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.9519 mL | 9.7593 mL | 19.5187 mL |
| 5 mM | 0.3904 mL | 1.9519 mL | 3.9037 mL |
| 10 mM | 0.1952 mL | 0.9759 mL | 1.9519 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (97.59 mM); Clear solution; Need ultrasonic
-
2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (4.88 mM); Clear solution
-
3.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (4.88 mM); Clear solution
References
- [1] Gan, X., et al., Treatment of mice with cromolyn sodium after reperfusion, but not prior to ischemia, attenuates small intestinal ischemia-reperfusion injury. Mol Med Rep, 2013. 8(3): p. 928-34.
- [2] Huang L, et al. Sinomenine-induced histamine release-like anaphylactoid reactions are blocked by tranilast via inhibiting NF-κB signaling. Pharmacol Res. 2017 Aug 31. pii: S1043-6618(17)30796-X.
- [3] Ng, G. and A. Ohlsson, Cromolyn sodium for the prevention of chronic lung disease in preterm infants. Cochrane Database Syst Rev, 2012. 6: p. CD003059.
Synonyms
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