[CAS NO. 1594094-64-0] CW-069
PRODUCTS SPECIFICATIONS [1594094-64-0]
DESCRIPTION [1594094-64-0]
Overview
| MDL | MFCD28009372 |
|---|---|
| Molecular Weight | 500.33 |
| Molecular Formula | C23H21IN2O3 |
| SMILES | O=C(NC1=CC=C(I)C=C1C(O)=O)[C@@H](NCC2=CC=CC=C2)CC3=CC=CC=C3 |
Summary
CW-069 is an allosteric inhibitor of microtubule motor protein HSET with an IC 50 of 75 μM.
IC50 & Target
|
HSET 75 μM (IC 50 ) |
In Vitro
CW-069 is an allosteric inhibitor of HSET with an IC 50 of 75 μM. CW-069 shows statistically significant selectivity over KSP. CW-069 potently suppresses N1E-115 cells, and less potently inhibits the NHDF cells, with IC 50 of 86 ± 10 μM and 181 ± 7 μM, respectively. CW-069 (100 or 200 μM) causes increased multipolar spindles in N1E-115 cells with supernumerary centrosomes and shows no effect on altering bipolar spindle morphology in normal human dermal fibroblast cells. CW-069 (200 μM) cacuses multipolar anaphase and cell death induced in N1E-115 cells via transfection with HSET siRNA, and antagonizes inhibition of KSP by monastrol, but does not exert mitotic arrest in HeLa cells [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 52 mg/mL ( 103.93 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.9987 mL | 9.9934 mL | 19.9868 mL |
| 5 mM | 0.3997 mL | 1.9987 mL | 3.9974 mL |
| 10 mM | 0.1999 mL | 0.9993 mL | 1.9987 mL |