[CAS NO. 1597489-14-9]  ML401

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PRODUCTS SPECIFICATIONS [1597489-14-9]

Catalog
HY-116814
Brand
MCE
CAS
1597489-14-9

DESCRIPTION [1597489-14-9]

Overview

MDL-
Molecular Weight419.74
Molecular FormulaC20H20BrClN2O
SMILESO=C(/C=C/C1=CC=C(C=C1)Br)N2CCN(CC2)CC3=CC=C(C=C3)Cl

For research use only. We do not sell to patients.

Summary

ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183 ) with an IC 50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC 50 =6.24 nM). ML401 shows good stability and no toxicity [1] .


IC50 & Target

IC50: 1.03 nM (EBI2) [1]


In Vitro

ML401 shows no toxicity (>50 μM) towards immortalized Fa2-N4 human hepatocytes and non-cytotoxic in MTT in both LnCap and IMR-32 cells (>50 μM) [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


In Vivo

ML401 shows very good stability in both human plasma and mouse plasma [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 10.42 mg/mL ( 24.82 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3824 mL 11.9121 mL 23.8243 mL
5 mM 0.4765 mL 2.3824 mL 4.7649 mL
10 mM 0.2382 mL 1.1912 mL 2.3824 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 1.04 mg/mL (2.48 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 1.04 mg/mL (2.48 mM); Clear solution

* All of the co-solvents are available by MCE.