[CAS NO. 1599432-08-2] NIBR189
PRODUCTS SPECIFICATIONS [1599432-08-2]
DESCRIPTION [1599432-08-2]
Overview
| MDL | MFCD13304236 |
|---|---|
| Molecular Weight | 429.31 |
| Molecular Formula | C21H21BrN2O3 |
| SMILES | O=C(N1CCN(C(C2=CC=C(OC)C=C2)=O)CC1)/C=C/C3=CC=C(Br)C=C3 |
1 Publications Citing Use of MCE
Summary
NIBR189 is an EBI2 (Epstein-Barr virus-induced gene 2) antagonist. NIBR189 inhibits human and mouse EBI2 with IC 50 s of 11 and 16 nM, respectively. NIBR189 can be used for the research of autoimmune diseases [1] .
In Vitro
NIBR189 (0-1 μM; 3 h) blocks migration of U937 cells
[1]
.
NIBR189 (0-10 μM) blocks oxysterol-dependent activation with an IC
50
value of 9 nM
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Migration Assay [1]
| Cell Line: | U937 cell lines |
| Concentration: | 0-1 μM |
| Incubation Time: | 3 hours |
| Result: | Blocked the direct migration of U937 cells with an IC 50 value of 0.3 nM. |
In Vivo
|
Mice
IV 1 mg/kg |
Mice
PO 3 mg/kg |
|
| CL (μL/min/mg) | 16 | |
| t 1/2 (h) | 1.1 | |
| V ss (L/kg) | 1.4 | |
| AUC (nmol·h/L) | 2435 | 3608 |
| C max (nmol/L) | 835 | |
| t max (h) | 1 | |
| F (%) | 49 |
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 116.47 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3293 mL | 11.6466 mL | 23.2932 mL |
| 5 mM | 0.4659 mL | 2.3293 mL | 4.6586 mL |
| 10 mM | 0.2329 mL | 1.1647 mL | 2.3293 mL |