[CAS NO. 160369-77-7] Fomivirsen sodium

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Catalog:	HY-109528
Brand:	MCE
CAS:	160369-77-7

Overview

MDL	-
Molecular Weight	7122.09
Molecular Formula	-
SMILES	[Fomivirsen (sodium)]

For research use only. We do not sell to patients.

Summary

Fomivirsen (ISIS-2922) sodium is an antisense 21 mer phosphorothioate oligonucleotide. Fomivirsen sodium is an antiviral agent that is used cytomegalovirus retinitis (CMV) research, incluiding in AIDs. Fomivirsen sodium binds to and degrades the mRNAs encoding CMV immediate-early 2 protein, thus inhibiting virus proliferation ^[1] ^[2] .

In Vitro

Antisense oligonucleotide acts a complementary nucleotide to the messenger RNA of the major immediate-early region proteins of human cytomegalovirus, it disrupts the replication of the virus through an antisense mechanism ^[1] .
Fomivirsen is 21-mer phosphorothioate ASO with CpG motif near its 5′ end, with the sequence 5′-GCG TTT GCT CTT CTT CTT GCG-3′, resulting in mRNA degradation by RNase H-mediated mechanism ^[2] .
Fomivirsen inhibits CMV replication in human retinal pigment epithelial (RPE) cells and in human fibroblast cells (MRC-5 cells) in a dose-dependent manner. The mean IC ₅₀ are 0.03 µM for RPE cells and 0.2 µM for MRC5 cells ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Phase
NCT00002187	Ionis Pharmaceuticals, Inc.\|NIH AIDS Clinical Trials Information Service	Cytomegalovirus Retinitis\|HIV Infections	Not Applicable
NCT00002356	Ionis Pharmaceuticals, Inc.\|NIH AIDS Clinical Trials Information Service	Cytomegalovirus Retinitis\|HIV Infections	Phase 2
NCT00002355	Ionis Pharmaceuticals, Inc.\|NIH AIDS Clinical Trials Information Service	Cytomegalovirus Retinitis\|HIV Infections	Not Applicable
NCT00002156	Ionis Pharmaceuticals, Inc.\|NIH AIDS Clinical Trials Information Service	Cytomegalovirus Retinitis\|HIV Infections	Phase 2

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

H ₂ O : 100 mg/mL ( 14.04 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.1404 mL	0.7020 mL	1.4041 mL
5 mM	0.0281 mL	0.1404 mL	0.2808 mL
10 mM	0.0140 mL	0.0702 mL	0.1404 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: PBS

Solubility: 100 mg/mL (14.04 mM); Clear solution; Need ultrasonic

* All of the co-solvents are available by MCE.

References

[1] M D de Smet, et al. Fomivirsen- a phosphorothioate oligonucleotide for the treatment of CMV retinitis. Ocul Immunol Inflamm. 1999 Dec;7(3-4):189-98.
[2] Anna Kilanowska, et al. In vivo and in vitro studies of antisense oligonucleotides – a review. (Review Article) RSC Adv., 2020, 10, 34501-34516

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